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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats
Food and Chemical Toxicology, Volume 48, No. 5, Year 2010
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Description
Doxorubicin (DOX) is a widely used cancer chemotherapeutic agent. However, it generates free oxygen radicals that result in serious dose-limiting cardiotoxicity. Supplementations with berries were proven effective in reducing oxidative stress associated with several ailments. The aim of the current study was to investigate the potential protective effect of cranberry extract (CRAN) against DOX-induced cardiotoxicity in rats. CRAN was given orally to rats (100. mg/kg/day for 10 consecutive days) and DOX (15. mg/kg; i.p.) was administered on the seventh day. CRAN protected against DOX-induced increased mortality and ECG changes. It significantly inhibited DOX-provoked glutathione (GSH) depletion and accumulation of oxidized glutathione (GSSG), malondialdehyde (MDA), and protein carbonyls in cardiac tissues. The reductions of cardiac activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) were significantly mitigated. Elevation of cardiac myeloperoxidase (MPO) activity in response to DOX treatment was significantly hampered. Pretreatment of CRAN significantly guarded against DOX-induced rise of serum lactate dehydrogenase (LDH), creatine phosphokinase (CK), creatine kinase-MB (CK-MB) as well as troponin I level. CRAN alleviated histopathological changes in rats' hearts treated with DOX. In conclusion, CRAN protects against DOX-induced cardiotoxicity in rats. This can be attributed, at least in part, to CRAN's antioxidant activity. © 2010 Elsevier Ltd.
Authors & Co-Authors
Elberry, Ahmed Abdullah
Saudi Arabia, Jeddah
King Abdulaziz University
Abdel-Naim, Ashraf Bahyeldeen
Saudi Arabia, Jeddah
King Abdulaziz University
Abdel Sattar, Essam A.
Saudi Arabia, Jeddah
King Abdulaziz University
Nagy, Ayman Abdel Hamid
Saudi Arabia, Jeddah
King Abdulaziz University
Mosli, Hisham Ahmed M.
Saudi Arabia, Jeddah
King Abdulaziz University
Mohamadin, Ahmed M.A.
Saudi Arabia, Madinah
Taibah University
Ashour, Osama M.
Saudi Arabia, Jeddah
King Abdulaziz University
Statistics
Citations: 115
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1016/j.fct.2010.02.008
ISSN:
02786915
Research Areas
Cancer
Noncommunicable Diseases