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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Expression of claudins 1, 4, 5, and 7 and occludin, and relationship with prognosis in squamous cell carcinoma of the tongue
Human Pathology, Volume 39, No. 8, Year 2008
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Description
Claudins and occludin are tight junctional proteins known to play a role in normal tissues and epithelial tumors. We analyzed the distribution patterns of claudins 1, 4, 5, and 7 and occludin in the superficial and invasive front of squamous cell carcinoma of the tongue of 97 patients and their relationship to cause-specific (squamous cell carcinoma of the tongue) patient survival (median follow-up period of 33.5 months; range, 1-234 months). Claudins 1 and 7 were strongly expressed, claudin 4 had moderate expression, whereas claudin 5 was least expressed. Occludin staining was mostly negative or very weak. Western blot analysis of tongue carcinoma (HSC-3) cells showed that all these proteins are also expressed in vitro. In cause-specific survival analysis, strong and low immunoreactivity of claudin 7 tended to be associated with decreased survival compared with medium immunoreactivity. We suggest that analyzing the immunohistologic staining levels of claudin 7 could be used for the prognostic purposes in patients with tongue squamous cell carcinoma. © 2008 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Bello, Ibrahim Olajide
Finland, Oulu
Oulun Yliopisto
Nigeria, Ibadan
University College Hospital, Ibadan
Vilen, Suvi Tuuli
Finland, Helsinki
Helsingin Yliopisto
Niinimaa, Ahti
Finland, Oulu
Oulun Yliopisto
Kantola, Saara
Finland, Oulu
Oulun Yliopisto
Soini, Ylermi M.J.
Finland, Oulu
Oulun Yliopisto
Salo, Tuula Anneli
Finland, Oulu
Oulun Yliopisto
Statistics
Citations: 67
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.humpath.2007.12.015
ISSN:
00468177
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study