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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Anti-HBc screening in Egyptian blood donors reduces the risk of hepatitis B virus transmission
Transfusion Medicine, Volume 18, No. 1, Year 2008
Notification
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Description
Occult hepatitis B virus (HBV) in blood donors is considered as a potential risk for transmission of HBV infection. The aim of this study was to determine the prevalence of anti-hepatitis B core antibody (anti-HBC) positivity in Egyptian blood donations as well as to estimate the frequency of HBV-DNA in anti-HBc-positive donations. The study included 760 Egyptian healthy blood donors, representing 26 different Egyptian governorates screened according to routine practice for the presence of hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibodies (Abs), HIV-1/2 Abs and Treponema Abs. The accepted blood units for donation were tested for the presence of total anti-HBc Abs by two tests. Positive units for anti-HBc were further tested for HBV-DNA by polymerase chain reaction. According to routine screening, a total of 48/760 units (6.3%) were rejected [38 (5%) HCV-Ab-positive units, 9 (1.18%) HbsAg-positive units and 1 (0.13%) Treponema-Ab-positive unit]. Among the accepted blood units for donation, prevalence of anti-HBc was 78/712 units (10.96%). HBV-DNA was detected in 9/78 (11.54%) of the anti-HBc-positive units, and thus, occult HBV infection was detected in 9/712 (1.26%) of the accepted blood donations. Implementing anti-HBc test to the routine assay for the forthcoming two decades would certainly eliminate possible HBV-infected units. Rejection of these units will be beneficial to decrease the risk of HBV transmission with its potential consequences particularly in immunocompromised recipients. © 2008 The Authors.
Authors & Co-Authors
El-Zayadi, Abdel Rahman
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Egypt, Giza
Cairo Liver Center
Ibrahim, Essam H.
Egypt, Cairo
National Organization for Drug Control and Research Egypt
Badran, Hanaa Mostafa
Egypt, Shibin el Kom
Menoufia University
Saeid, A.
Egypt, Giza
Cairo Liver Center
Moneib, Nayera Ahmed
Egypt, Cairo
Faculty of Pharmacy
Shemis, Mohamed Abbas
Egypt, Giza
Biochemistry and Medicinal Chemistry Division
Abdel-Sattar, R. M.
Egypt, Cairo
Egyptian Ministry of Health and Population
Ahmady, A. M.
Egypt, Cairo
Faculty of Pharmacy
El-Nakeeb, Adham
Egypt, Giza
Cairo Liver Center
Statistics
Citations: 63
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1111/j.1365-3148.2007.00806.x
ISSN:
09587578
e-ISSN:
13653148
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study