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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo
Journal of Virology, Volume 88, No. 1, Year 2014
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Description
Alpha interferon (IFN-α) suppresses human immunodeficiency virus type 1 (HIV-1) replication in vitro by inducing cell-intrinsic retroviral restriction mechanisms. We investigated the effects of IFN-α/ribavirin (IFN-α/riba) treatment on 34 anti-HIV-1 restriction factors in vivo. Expression of several anti-HIV-1 restriction factors was significantly induced by IFN-α/riba in HIV/ hepatitis C virus (HCV)-coinfected individuals. Fold induction of cumulative restriction factor expression in CD4+ T cells was significantly correlated with viral load reduction during IFN-α/riba treatment (r2 = 0.649; P<0.016). Exogenous IFN-α induces supraphysiologic restriction factor expression associated with a pronounced decrease in HIV-1 viremia. © 2014, American Society for Microbiology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3911728/bin/supp_88_1_763__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3911728/bin/JVI.02687-13_zjv999098490so1.pdf
Authors & Co-Authors
Abdel-Mohsen, Mohamed T.
United States, San Francisco
Ucsf School of Medicine
United States, San Diego
Va San Diego Healthcare System
Deng, Xutao
United States, San Francisco
Vitalant Research Institute
Liegler, Teri J.
United States, San Francisco
Ucsf School of Medicine
Guatelli, John C.
United States, La Jolla
University of California, San Diego
United States, San Diego
Va San Diego Healthcare System
Salama, M. S.
Egypt, Cairo
College of Science
Ghanem, Hussam E.A.
Egypt, Cairo
College of Science
Rauch, Andri
Switzerland, Bern
University Hospital Bern
Ledergerber, Bruno
Switzerland, Zurich
Universitatsspital Zurich
Deeks, Steven G.
United States, San Francisco
Ucsf School of Medicine
Günthard, Hüldrych Fritz
Switzerland, Zurich
Universitatsspital Zurich
Wong, Joseph K.
United States, San Francisco
Ucsf School of Medicine
United States
Va Medical Center
Pillai, Satish K.
United States, San Francisco
Ucsf School of Medicine
United States, San Francisco
Vitalant Research Institute
United States
Va Medical Center
Statistics
Citations: 33
Authors: 12
Affiliations: 8
Identifiers
Doi:
10.1128/JVI.02687-13
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Infectious Diseases