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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies
Cell, Volume 158, No. 3, Year 2014
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Description
Development of strategies for induction of HIV-1 broadly neutralizing antibodies (bnAbs) by vaccines is a priority. Determining the steps of bnAb induction in HIV-1-infected individuals who make bnAbs is a key strategy for immunogen design. Here, we study the B cell response in a bnAb-producing individual and report cooperation between two B cell lineages to drive bnAb development. We isolated a virus-neutralizing antibody lineage that targeted an envelope region (loop D) and selected virus escape mutants that resulted in both enhanced bnAb lineage envelope binding and escape mutant neutralization - traits associated with increased B cell antigen drive. Thus, in this individual, two B cell lineages cooperated to induce the development of bnAbs. Design of vaccine immunogens that simultaneously drive both helper and broadly neutralizing B cell lineages may be important for vaccine-induced recapitulation of events that transpire during the maturation of neutralizing antibodies in HIV-1-infected individuals. © 2014 Elsevier Inc.
Authors & Co-Authors
Gao, Feng
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Bonsignori, Mattia
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Liao, Huaxin
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Kumar, Amit
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Xia, Shi Mao
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Lu, Xiaozhi
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Cai, Fangping
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Hwang, Kwanki
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Song, Hongshuo
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Zhou, Tongqing
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Lynch, Rebecca M.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Alam, S. Munir
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Moody, Michael Anthony
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Ferrari, Guido
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Berrong, Mark
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Kelsoe, Garnett H.
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Shaw, George M.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Hahn, Beatrice H.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Montefiori, David Charles
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Kamanga, Gift
Malawi, Lilongwe
Unc Project-malawi
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Cohen, Myron S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Hraber, Peter T.
United States, Los Alamos
Los Alamos National Laboratory Theoretical Division
Kwong, Peter D.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Korber, Bette T.
United States, Los Alamos
Los Alamos National Laboratory Theoretical Division
Mascola, John R.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Kepler, Thomas B.
United States, Boston
Boston University
Haynes, Barton F.
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University
Statistics
Citations: 266
Authors: 27
Affiliations: 8
Identifiers
Doi:
10.1016/j.cell.2014.06.022
ISSN:
00928674
e-ISSN:
10974172
Research Areas
Infectious Diseases