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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer
Nature Genetics, Volume 46, No. 10, Year 2014
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Description
Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10 â '8; 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease. © 2014 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Al Olama, Ali Amin
United Kingdom, Cambridge
University of Cambridge
Kóte-Jarai, Zsofia S.
United Kingdom, London
The Institute of Cancer Research
Berndt, Sonja I.
United States, Bethesda
National Institutes of Health Nih
Conti, David V.
United States, Los Angeles
University of Southern California
Schumacher, Fredrick R.
United States, Los Angeles
University of Southern California
Han, Ying
United States, Los Angeles
University of Southern California
Benlloch, Sara
United Kingdom, Cambridge
University of Cambridge
Hazelett, Dennis J.
United States, Los Angeles
University of Southern California
Wang, Zhaoming
United States, Bethesda
National Institutes of Health Nih
United States, Frederick
Saic-frederick
Saunders, Edward J.
United Kingdom, London
The Institute of Cancer Research
Leongamornlert, Daniel A.
United Kingdom, London
The Institute of Cancer Research
Lindstrom̈, Sara
United States, Boston
Harvard T.h. Chan School of Public Health
Jugurnauth-Little, Sara
United Kingdom, London
The Institute of Cancer Research
Dadaev, Tokhir
United Kingdom, London
The Institute of Cancer Research
Tymrakiewicz, Malgorzata
United Kingdom, London
The Institute of Cancer Research
Stram, Daniel O.
United States, Los Angeles
University of Southern California
Rand, Kristin A.
United States, Los Angeles
University of Southern California
Wan, Peggy C.
United States, Los Angeles
University of Southern California
Stram, Alex H.
United States, Los Angeles
University of Southern California
Sheng, Xin
United States, Los Angeles
University of Southern California
Pooler, Loreall C.
United States, Los Angeles
University of Southern California
Park, Karen
United States, Los Angeles
University of Southern California
Xia, Lucy Y.
United States, Los Angeles
University of Southern California
Tyrer, Jonathan P.
United Kingdom, Cambridge
University of Cambridge
Kolonel, Laurence N.
United States, Honolulu
University of Hawaiʻi Cancer Center
Le Marchand, Loic̈
United States, Honolulu
University of Hawaiʻi Cancer Center
Hoover, Robert N.
United States, Bethesda
National Institutes of Health Nih
MacHiela, Mitchell J.
United States, Bethesda
National Institutes of Health Nih
Yeager, Meredith S.
United States, Bethesda
National Institutes of Health Nih
Burdett, Laurie A.
United States, Bethesda
National Institutes of Health Nih
Chung, Charles C.
United States, Bethesda
National Institutes of Health Nih
Hutchinson, Amy A.
United States, Bethesda
National Institutes of Health Nih
Yu, Kai
United States, Bethesda
National Institutes of Health Nih
Goh, Cheeleng
United Kingdom, London
The Institute of Cancer Research
Ahmed, Mahbubl Yahya
United Kingdom, London
The Institute of Cancer Research
Govindasami, Koveela
United Kingdom, London
The Institute of Cancer Research
Guy, Michelle
United Kingdom, London
The Institute of Cancer Research
Tammela, Teuvo L.J.
Finland, Tampere
Tampere University
Auvinen, Anssi Pekka
Finland, Tampere
Tampere University
Wahlfors, Tiina A.
Finland, Tampere
Fimlab Laboratoriot oy
Schleutker, Johanna
Finland, Tampere
Fimlab Laboratoriot oy
Finland, Turku
Turun Yliopisto
Visakorpi, Tapio
Finland, Tampere
University Hospital of Tampere
Leinonen, Katri A.
Finland, Tampere
University Hospital of Tampere
Xu, Jienfiang Feng
United States, Winston Salem
Wake Forest University School of Medicine
Aly, Markus
Sweden, Stockholm
Karolinska Institutet
Sweden, Danderyd
Danderyds Sjukhus
Donovan, Jenny L.
United Kingdom, Bristol
University of Bristol
Travis, Ruth C.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Key, Timothy J.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Siddiq, Afshan
United Kingdom, London
Imperial College London
Canzian, Federico
Germany, Heidelberg
German Cancer Research Center
Khaw, Kay Tee T.
United Kingdom, Cambridge
University of Cambridge
Takahashi, Atsushi
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Kubo, Michiaki
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Pharoah, Paul D.P.
United Kingdom, Cambridge
University of Cambridge
Pashayan, Nora
United Kingdom, Cambridge
University of Cambridge
Weischer, Maren
Denmark, Copenhagen
Copenhagen University Hospital
Nordestgaard, BØrge Grønne
Denmark, Copenhagen
Copenhagen University Hospital
Denmark, Copenhagen
Københavns Universitet
Nielsen, Sune Fallgaard
Denmark, Copenhagen
Copenhagen University Hospital
Denmark, Copenhagen
Københavns Universitet
Klarskov, Peter
Denmark, Copenhagen
Copenhagen University Hospital
Røder, Andreas
Denmark, Copenhagen
Copenhagen University Hospital
Iversen, Peter
Denmark, Copenhagen
Copenhagen University Hospital
Thibodeau, Stephen N.
United States, Rochester
Mayo Clinic
McDonnell, Shannon K.
United States, Rochester
Mayo Clinic
Schaid, Daniel J.
United States, Rochester
Mayo Clinic
Stanford, Janet L.
United States, Seattle
Fred Hutchinson Cancer Center
United States, Seattle
University of Washington
Kolb, Suzanne
United States, Seattle
Fred Hutchinson Cancer Center
Holt, Sarah K.
United States, Seattle
Fred Hutchinson Cancer Center
Knudsen, Beatrice S.
United States, Los Angeles
Cedars-sinai Medical Center
Coll, Antonio Hurtado
Canada, Vancouver
Prostate Center
Gapstur, Susan M.
United States, Kennesaw
American Cancer Society
Diver, William Ryan
United States, Kennesaw
American Cancer Society
Stevens, Victoria L.
United States, Kennesaw
American Cancer Society
Maier, Christiane
Germany, Ulm
Universitätsklinikum Ulm
Luedeke, Manuel
Germany, Ulm
Universitätsklinikum Ulm
Herkommer, Kathleen
Germany, Munich
Technische Universität München
Rinckleb, Antje E.
Germany, Ulm
Universitätsklinikum Ulm
Strom, Sara S.
United States, Houston
The University of Texas Md Anderson Cancer Center
Pettaway, Curtis A.
United States, Houston
The University of Texas Md Anderson Cancer Center
Yeboah, Edward D.
Ghana, Accra
University of Ghana
Ghana, Accra
Korle bu Teaching Hospital
Tettey, Yao
Ghana, Accra
University of Ghana
Ghana, Accra
Korle bu Teaching Hospital
Biritwum, Richard Berko
Ghana, Accra
University of Ghana
Ghana, Accra
Korle bu Teaching Hospital
Adjei, Andrew Anthony
Ghana, Accra
University of Ghana
Ghana, Accra
Korle bu Teaching Hospital
Tay, Evelyn
Ghana, Accra
University of Ghana
Ghana, Accra
Korle bu Teaching Hospital
Truelove, Ann L.
United States, Rockville
Westat, Inc.
Niwa, Shelley
United States, Rockville
Westat, Inc.
Chokkalingam, Anand P.
United States, Berkeley
University of California, Berkeley
Cannon-Albright, Lisa Anne
United States, Salt Lake City
University of Utah School of Medicine
United States
Va Medical Center
Cybulski, Cezary
Poland, Szczecin
Pomeranian Medical University in Szczecin
Wokołorczyk, Dominika
Poland, Szczecin
Pomeranian Medical University in Szczecin
Kluzńiak, Wojciech
Poland, Szczecin
Pomeranian Medical University in Szczecin
Park, Jong-yun
United States, Tampa
Moffitt Cancer Center
Sellers, Thomas
United States, Tampa
Moffitt Cancer Center
Lin, Huiyi
United States, Tampa
Moffitt Cancer Center
Isaacs, William B.
United States, Baltimore
Johns Hopkins Medicine
Partin, Alan Wayne
United States, Baltimore
Johns Hopkins Medicine
Brenner, Hermann
Germany, Heidelberg
German Cancer Research Center
Dieffenbach, Aida Karina
Germany, Heidelberg
German Cancer Research Center
Stegmaier, Christa
Germany, Saarbrucken
Saarland Cancer Registry
Chen, Constance M.
United States, Boston
Harvard T.h. Chan School of Public Health
Giovannucci, Edward Luciano
United States, Boston
Harvard T.h. Chan School of Public Health
Ma, Jing
United States, Boston
Brigham and Women's Hospital
Stampfer, Meir J.
United States, Boston
Harvard T.h. Chan School of Public Health
Penney, Kathryn L.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Brigham and Women's Hospital
Mucci, Lorelei Ann
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Brigham and Women's Hospital
John, Esther M.
United States, Fremont
Cancer Prevention Institute of California
United States, Stanford
Stanford University School of Medicine
Ingles, Sue Ann
United States, Los Angeles
University of Southern California
Kittles, Rick A.
United States, Chicago
University of Illinois at Chicago
Murphy, Adam Bryant
United States, Evanston
Northwestern University
Pandha, Hardev S.
United Kingdom, Guildford
University of Surrey
Michael, Agnieszka
United Kingdom, Guildford
University of Surrey
Kierzek, Andrzej M.
United Kingdom, Guildford
University of Surrey
Blot, William James
United States, Rockville
International Epidemiology Institute
United States, Nashville
Vanderbilt University School of Medicine
Signorello, Lisa Beth
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Brigham and Women's Hospital
Zheng, Wei
United States, Nashville
Vanderbilt University School of Medicine
Albanes, Demetrius
United States, Bethesda
National Institutes of Health Nih
Virtamo, Jarmo R.K.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Weinstein, Stephanie J.
United States, Bethesda
National Institutes of Health Nih
Nemesure, Barbara Berger
United States, Stony Brook
Stony Brook University
Carpten, John David
United States, Phoenix
Translational Genomics Research Institute
Leske, Maria Cristina
United States, Stony Brook
Stony Brook University
Wu, Suhyuh
United States, Stony Brook
Stony Brook University
Hennis, Anselm J.M.
United States, Stony Brook
Stony Brook University
Jamaica, Kingston
The University of the West Indies
Kibel, Adam S.
United States, Boston
Dana-farber Cancer Institute
Rybicki, Benjamin A.
United States, Detroit
Henry Ford Hospital
Neslund-Dudas, Christine M.
United States, Detroit
Henry Ford Hospital
Hsing, Ann Wu
United States, Fremont
Cancer Prevention Institute of California
United States, Stanford
Stanford University School of Medicine
Chu, Lisa W.
United States, Fremont
Cancer Prevention Institute of California
United States, Stanford
Stanford University School of Medicine
Goodman, Phyllis J.
United States, Seattle
Fred Hutchinson Cancer Center
Klein, Eric A.
United States, Cleveland
Cleveland Clinic Foundation
Zheng, Siquan Lilly
United States, Winston Salem
Wake Forest University School of Medicine
Batra, Jyotsna
Australia, Woolloongabba
Translational Research Institute Australia
Clements, Judith Ann
Australia, Woolloongabba
Translational Research Institute Australia
Spurdle, Amanda B.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Teixeira, Manuel Rodrigues
Portugal, Porto
Instituto Português de Oncologia do Porto fg
Portugal, Porto
Universidade do Porto
Paulo, Paula
Portugal, Porto
Instituto Português de Oncologia do Porto fg
Maia, Sofia F.
Portugal, Porto
Instituto Português de Oncologia do Porto fg
Slavov, Ch K.
Bulgaria, Sofia
Medical University of Sofia
Kaneva, Radka
Bulgaria, Sofia
Medical University of Sofia
Mitev, Vanio Ivanov
Bulgaria, Sofia
Medical University of Sofia
Witte, John S.
United States, San Francisco
University of California, San Francisco
Casey, Graham R.
United States, Los Angeles
University of Southern California
Gillanders, Elizabeth M.
United States, Rockville
National Cancer Institute Nci
Seminara, Daniela
United States, Rockville
National Cancer Institute Nci
Riboli, Elio B.
United Kingdom, London
Imperial College London
Hamdy, Freddie Charles
United Kingdom, Oxford
University of Oxford
Coetzee, Gerhard A.
United States, Los Angeles
University of Southern California
Li, Qiyuan
United States, Boston
Dana-farber Cancer Institute
Freedman, Matthew Lee
United States, Boston
Dana-farber Cancer Institute
Hunter, D. J.
United States, Boston
Harvard T.h. Chan School of Public Health
Muir, Kenneth Ross
United Kingdom, Manchester
The University of Manchester
United Kingdom, Coventry
University of Warwick
Grönberg, Henrik
Sweden, Stockholm
Karolinska Institutet
Neal, David E.
United Kingdom, London
Cancer Research uk
United Kingdom, Cambridge
Addenbrooke's Hospital
Southey, Melissa Caroline
Australia, Melbourne
University of Melbourne
Giles, Graham G.
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Severi, Gianluca
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Italy, Torino
Human Genetics Foundation
Cook, Michael Blaise
United States, Bethesda
National Institutes of Health Nih
Nakagawa, Hidewaki
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Wiklund, Fredrik E.
Sweden, Stockholm
Karolinska Institutet
Kraft, Peter L.
United States, Boston
Harvard T.h. Chan School of Public Health
Chanock, Stephen J.
United States, Bethesda
National Institutes of Health Nih
Henderson, Brian E.
United States, Los Angeles
University of Southern California
d'Adamo, Adamo P.
United Kingdom, Cambridge
University of Cambridge
Eeles, Rosalind A.
United Kingdom, London
The Institute of Cancer Research
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Haiman, Christopher A.
United States, Los Angeles
University of Southern California
Statistics
Citations: 426
Authors: 164
Affiliations: 71
Identifiers
Doi:
10.1038/ng.3094
ISSN:
10614036
Research Areas
Cancer
Study Approach
Systematic review
Participants Gender
Male