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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The HIV-1 epidemic: Low- to middle-income countries
Cold Spring Harbor Perspectives in Medicine, Volume 2, No. 3, Year 2012
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Description
Low- to middle-income countries bear the overwhelming burden of the human immunodeficiency virus type 1 (HIV-1) epidemic in terms of the numbers of their citizens living with HIV/AIDS (acquired immunodeficiency syndrome), the high degrees of viral diversity often involving multiple HIV-1 clades circulating within their populations, and the social and economic factors that compromise current control measures. Distinct epidemics have emerged in different geographical areas. These epidemics differ in their severity, the population groups they affect, their associated risk behaviors, and the viral strains that drive them. In addition to inflicting great human cost, the high burden of HIV infection has a major impact on the social and economic development of many low- to middle-income countries. Furthermore, the high degrees of viral diversity associated with multiclade HIV epidemics impacts viral diagnosis and pathogenicity and treatment and poses daunting challenges for effective vaccine development. © 2012 Cold Spring Harbor Laboratory Press; all rights reserved.
Authors & Co-Authors
Shao, Yiming
China, Beijing
National Center for Aids/std Control and Prevention
Williamson, Carolyn
South Africa, Johannesburg
National Health Laboratory Service
Statistics
Citations: 107
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1101/cshperspect.a007187
e-ISSN:
21571422
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study