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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection
Journal of Immunology, Volume 184, No. 2, Year 2010
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Description
IL-17 is a potent effector cytokine involved in inflammatory response and antimicrobial defense. We report that SIV infection of rhesus macaques (RMs) results in the emergence of IL-17-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-β and IL-18 expression. This subset, which exhibits phenotypic markers of NK T cells (NKT), rather than Th17 CD4 cells, persists during the chronic phase and is higher in noncontrollers SIV-infected RMs compared with controllers SIV-infected RMs. In contrast, in the nonpathogenic model of SIVagm infection of African green monkeys, no change in the level of IL-17-expressing cells is observed in lymphoid organs. Consistent with the emergence of TGF-β and IL-18 during the acute phase in SIV-infected RMs, but not in SIV-infected African green monkeys, we demonstrate that in vitro TGF-β and IL-18 induce the differentiation and expansion of IL-17+NKT+. Altogether, these results demonstrate that IL-17-producing NKT are associated with the pathogenesis of SIV in RMs and suggest that TGF-β and IL-18 play a role in their development. Copyright © 2010 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Campillo-Gimenez, Laure
France, Creteil
Hôpital Henri Mondor
Cumont, Marie Christine
France, Paris
Institut Pasteur, Paris
Fay, Michèle
France, Paris
Université Paris Cité
Kared, Hassen
France, Creteil
Hôpital Henri Mondor
Monceaux, Valérie
France, Paris
Institut Pasteur, Paris
Diop, Ousmane Madiagne
Senegal, Dakar
Institut Pasteur de Dakar
Müller-Trutwin, Michaela C.
France, Paris
Institut Pasteur, Paris
Hurtrel, Bruno
France, Paris
Institut Pasteur, Paris
Lévy, Yvés
France, Creteil
Hôpital Henri Mondor
Zaunders, J.
Australia, Sydney
St. Vincent's Hospital Sydney
Dy, Michel
France, Paris
Université Paris Cité
Leite-De-Moraes, Maria C.
France, Paris
Université Paris Cité
Elbim, Carole
France, Creteil
Hôpital Henri Mondor
France, Paris
Centre de Recherche Des Cordeliers
Estaquier, Jérôme
France, Creteil
Hôpital Henri Mondor
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 60
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.4049/jimmunol.0902316
ISSN:
00221767
e-ISSN:
15506606
Research Areas
Infectious Diseases