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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Infection Reduction Using Antibiotic-Coated Inflatable Penile Prosthesis
Urology, Volume 70, No. 2, Year 2007
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Description
Objectives: Inflatable penile prosthesis (IPP) infection remains a devastating surgical complication. American Medical Systems recently introduced an IPP with a coating of minocycline HCL and rifampin (InhibiZone). We report our experience with this coating and compare the rate of infection with our historical rate. Methods: A total of 467 patients receiving InhibiZone-coated IPPs were followed up for infection. The patients were stratified into four groups: nondiabetic, first-time (virgin) implants; diabetic, virgin implants; revision without washout; and revision with antiseptic solution washout. All patients were observed for longer than 1 year. The infection rates were compared with our published data of noncoated IPPs. Results: No infections developed among the 223 virgin implants in nondiabetic patients. Of the 83 diabetic patients with virgin implants, 1 developed an infection (1%). Of the 39 revision patients without washout, 4 (10%) had infections. When an antiseptic washout was used in patients requiring revision, the infection rate dropped to 3% (4 of 123). Compared with our previous publications of infection rates with noncoated implants, InhibiZone-coated IPPs showed a statistically significant reduction in infection in virgin nondiabetic, virgin diabetic, and revision with washout implants. No reduction in the infection rate occurred among revision patients without washout. Conclusions: Antibiotic-coated implants become infected less often in virgin, nondiabetic and virgin, diabetic patients than in our historical experience with noncoated implants. However, antibiotic-coated implants used in revision surgery did not reduce the infection rate unless adjunctive antiseptic solution washout was also used. © 2007 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Wilson, Steven K.
United States, Little Rock
University of Arkansas for Medical Sciences
Zumbé, Juergen
Germany, Leverkusen
Klinikum-lev .de
Henry, Gerard D.
United States, Shreveport
Regional Urology
Salem, Emad A.
United States, Little Rock
University of Arkansas for Medical Sciences
Egypt, Zagazig
Zagazig University
Delk, John R.
United States, Little Rock
University of Arkansas for Medical Sciences
Cleves, Mario Alberto
United States, Little Rock
University of Arkansas for Medical Sciences
Statistics
Citations: 132
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.urology.2007.03.058
ISSN:
00904295
e-ISSN:
15279995
Research Areas
Health System And Policy