Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Diversity of risk of mother-to-child HIV-1 transmission according to feeding practices, CD4 cell count, and haemoglobin concentration in a South African cohort
Tropical Medicine and International Health, Volume 13, No. 3, Year 2008
Notification
URL copied to clipboard!
Description
Objective: To estimate the probabilities of intrapartum and postpartum HIV-1 mother-to-child-transmission according to various feeding practices (formula feeding, exclusive breastfeeding, or mixed-feeding) and to other mother and infant covariates. Methods: We used the promotion time model extended to multiple exposures to study the probability of infection attributable to each transmission occasion. Blood samples from 551 infants from Durban (South Africa) born to HIV-1 positive untreated mothers between 1995 and 1998 were sequentially tested until 15 months. Results: The probability of infection attributable to in utero and intrapartum transmission was 21.88% (18.71-25.20) and was not significantly associated with the feeding practice. The probability of infection attributable to postnatal transmission through exclusive breastfeeding was negligible -0.7% (0-2.5) for 6 months of exclusive breastfeeding - in comparison with that observed with mixed-feeding -6.15% (3.16-9.57) for 6 months of mixed-feeding. Maternal CD4 cell count and gestational age were significant predictors of intrapartum transmission probability while maternal CD4 cell count and maternal haemoglobin concentration were significant predictors of postpartum transmission probability. Conclusion: Decisions about appropriate infant feeding practices should take into account the difference in postpartum transmission risk between exclusive and mixed-feeding. Mixed-feeding should be all the more avoided that mothers have poor immunological statuses and low haemoglobin concentrations. © 2008 Blackwell Publishing Ltd.
Authors & Co-Authors
Tournoud, M.
France, Lyon
Chu de Lyon
France, Villeurbanne
Université Claude Bernard Lyon 1
France, Villeurbanne
Laboratoire de Biométrie et Biologie Évolutive
France, Lyon
Laboratoire Biostatistique-santé Ucbl1
Écochard, René
France, Lyon
Chu de Lyon
France, Villeurbanne
Université Claude Bernard Lyon 1
France, Villeurbanne
Laboratoire de Biométrie et Biologie Évolutive
Kuhn, Louise
United States, New York
Mailman School of Public Health
Coutsoudis, Anna
South Africa, Durban
University of Kwazulu-natal
Statistics
Citations: 16
Authors: 4
Affiliations: 6
Identifiers
Doi:
10.1111/j.1365-3156.2008.02004.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
South Africa