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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Acute renal failure complicating severe preeclampsia requiring admission to an obstetric intensive care unit
American Journal of Obstetrics and Gynecology, Volume 186, No. 2, Year 2002
Notification
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Description
OBJECTIVE: To determine risk factors and outcomes for women with severe preeclampsia and renal failure. STUDY DESIGN: Retrospective study from 1995 to 1998 of all women with renal failure who were admitted to the obstetric intensive care unit at Groote Schuur Hospital, South Africa. A total of 89 women were identified with severe preeclampsia defined as blood pressure ≥160/110 mm Hg and ≥2+ proteinuria, renal failure defined as a creatinine level of ≥1.13 mg/dL, and oliguria defined as <100 mL urine produced in 4 hours; 72 charts were available for analysis. A comparison was made between the 3 groups, which were defined by the maximum recorded creatinine levels. RESULTS: Of the 72 women, 31 women (43%) were primiparous and 41 (57%) were multiparous. Median gestation at delivery was 32 weeks (range, 21-40 weeks). The median maximum creatinine was 3.85 mg/dL (range, 1.13-12.50 mg/dL). Twelve women (16%) had a history of chronic renal disease or hypertension, and 36 women (50%) had HELLP syndrome and 23 (32%) abruptio placentae. All women with severe renal impairment had either abruptio placentae or hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. Perinatal mortality was 38% (27/72). However, in this series only 7 women (10%) required dialysis in the short term and none required long-term dialysis or kidney transplant. There were no maternal deaths. CONCLUSIONS: In women with severe preeclampsia and renal failure, major obstetric complications were common and perinatal outcome was poor. However, the need for dialysis was infrequent, with only 10% women requiring transient dialysis, and there were no cases of chronic renal failure that required dialysis or kidney transplant. © 2002, Mosby, Inc.
Authors & Co-Authors
Drakeley, Andrew John
United Kingdom, Cambridge
Department of Obstetrics and Gynaecology
Le Roux, Paul Andre
United Kingdom, Cambridge
Department of Obstetrics and Gynaecology
Anthony, John A.
United Kingdom, Cambridge
Department of Obstetrics and Gynaecology
Penny, James A.
United Kingdom, Cambridge
Department of Obstetrics and Gynaecology
Statistics
Citations: 140
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1067/mob.2002.120279
ISSN:
00029378
Research Areas
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cohort Study
Study Locations
South Africa
Participants Gender
Female