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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils
Parasite Immunology, Volume 35, No. 7-8, Year 2013
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Description
IL-33, a proposed alarmin, stimulates innate immune cells and Th2 cells to produce IL-13 and is rapidly upregulated upon antigen exposure in murine helminth infection. The human IL-33 response to helminth antigen was analysed in Malians infected with Schistosoma haematobium by disrupting parasite integrity via chemotherapy. Plasma IL-33 was measured pretreatment, and 24 h and 9 weeks post-treatment. At 24 h post-treatment, IL-33 levels were low. Nine week post-treatment IL-33 levels were elevated and were associated with an increase in intracellular IL-13 in eosinophils. Up-regulation of intracellular IL-13 in eosinophils was also associated with eosinophil expression of ST2L, the IL-33 receptor. IL-33 may play an important downstream role in the human response to schistosome adult worm antigen exposure. © 2013 John Wiley & Sons Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4463766/bin/pim0035-0224-sd1.docx
Authors & Co-Authors
Wilson, Shona
United Kingdom, Cambridge
University of Cambridge
Jones, Frances M.
United Kingdom, Cambridge
University of Cambridge
Fofana, H. K.M.
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Landouré, Aly
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Kimani, Gachuhi G.
Kenya, Nairobi
Kenya Medical Research Institute
Mwatha, Joseph K.
Kenya, Nairobi
Kenya Medical Research Institute
Sacko, Moussa
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Vennervald, Birgitte Jyding
Denmark, Copenhagen
Dbl -center for Health Research and Development
Dunne, David William
United Kingdom, Cambridge
University of Cambridge
Statistics
Citations: 138
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1111/pim.12035
ISSN:
01419838
e-ISSN:
13653024
Research Areas
Cancer