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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Epidemiological synergy of trichomonas vaginalis and HIV in Zimbabwean and South African women
Sexually Transmitted Diseases, Volume 37, No. 7, Year 2010
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Description
Background: Trichomonas vaginalis (T. vaginalis) is the most common nonviral sexually transmitted infection in the world. Despite the coexisting global epidemics of T. vaginalis and HIV, little attention has focused on the emerging evidence that T. vaginalis increases susceptibility to, and potentially transmission of, HIV. Methods: We evaluated T. vaginalis infection in the context of a multisite, randomized controlled trial amongst women in South Africa and Zimbabwe, to determine first, if risk of HIV acquisition was increased among women recently infected with T. vaginalis, and second, if risk of T. vaginalis acquisition was increased among women infected with HIV. Results: After controlling for potential confounders, participants infected with T. vaginalis were more likely to test positive for HIV at their following visit, compared to participants uninfected with T. vaginalis (adjusted hazard ratio = 2.05; 95% CI, 1.05-4.02). Similarly, HIV-positive participants were twice as likely to have acquired T. vaginalis infection at the following visit, compared to HIV-negative participants (adjusted hazard ratio = 2.12; 95% CI, 1.35-3.32). Conclusions: We found an increased risk of both HIV acquisition associated with T. vaginalis infection and risk of T. vaginalis acquisition associated with HIV infection. This bidirectional relationship represents a potentially important factor in sustaining the HIV epidemic in populations where T. vaginalis is endemic. Copyright © 2010 American Sexually Transmitted Diseases Association. All rights reserved.
Authors & Co-Authors
Napierala-Mavedzenge, Sue Naperiela
Unknown Affiliation
van der Pol, Barbara J.
Unknown Affiliation
Cheng, Helen Y.
Unknown Affiliation
Montgomery, Elizabeth T.
Unknown Affiliation
Blanchard, Kelly
Unknown Affiliation
De Bruyn, Guy
Unknown Affiliation
Ramjee, Gita A.
Unknown Affiliation
van der Straten, Ariane
Unknown Affiliation
Statistics
Citations: 133
Authors: 8
Affiliations: 8
Identifiers
Doi:
10.1097/OLQ.0b013e3181cfcc4b
ISSN:
01485717
Research Areas
Environmental
Infectious Diseases
Sexual And Reproductive Health
Study Approach
Quantitative
Study Locations
South Africa
Zimbabwe
Participants Gender
Female