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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behavior
Neuropsychopharmacology, Volume 33, No. 2, Year 2008
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Description
A functional VNTR polymorphism in the promoter of the monoamine oxidase A gene (MAOA-LPR) has previously been shown to be an important predictor of antisocial behavior in men. Testosterone analogues are known to interact with the MAOA promoter in vitro to influence gene transcription as well as in vivo to influence CSF levels of the MAO metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) in human males. We examined the possible joint effects of testosterone (measured in CSF) and MAOA-LPR genotype on antisocial personality disorder and scores on the Brown-Goodwin Aggression scale in 95 unrelated male criminal alcoholics and 45 controls. The results confirm that MAOA genotype and CSF testosterone interact to predict antisocial behaviors. The MAOA/testosterone interaction also predicted low levels of CSF MHPG, which tentatively suggests the possibility that the interaction may be mediated by a direct effect on gene transcription. If replicated these findings offer plausible explanations for previous inconsistencies in studies of the relationship between testosterone and male human aggression, as well as for how MAOA genotype may influence aggressive behavior in human males. © 2008 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Sjöberg, Rickard L.
Sweden, Uppsala
Uppsala Universitet
United States, Bethesda
National Institute on Alcohol Abuse and Alcoholism Niaaa
Ducci, Francesca
United States, Bethesda
National Institute on Alcohol Abuse and Alcoholism Niaaa
Barr, C. S.
United States, Bethesda
National Institute on Alcohol Abuse and Alcoholism Niaaa
Newman, Timothy K.
South Africa, Cape Town
University of Cape Town
Dell’Osso, Liliana
Italy, Pisa
Università Di Pisa
Virkkunen, Matti
Finland, Helsinki
Helsingin Yliopisto
Goldman, David A.
United States, Bethesda
National Institute on Alcohol Abuse and Alcoholism Niaaa
Statistics
Citations: 137
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1038/sj.npp.1301417
ISSN:
0893133X
Research Areas
Genetics And Genomics
Participants Gender
Male