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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Gene expression defines natural changes in mammalian lifespan
Aging Cell, Volume 14, No. 3, Year 2015
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Description
Mammals differ more than 100-fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages. To understand the relationship between lifespan and variation in gene expression, we carried out RNA-seq-based gene expression analyses of liver, kidney, and brain of 33 diverse species of mammals. Our analysis uncovered parallel evolution of gene expression and lifespan, as well as the associated life-history traits, and identified the processes and pathways involved. These findings provide direct insights into how nature reversibly adjusts lifespan and other traits during adaptive radiation of lineages. © 2015 The Authors.
Authors & Co-Authors
Turanov, Anton A.
United States, Boston
Brigham and Women's Hospital
Lee, Sang Goo
South Korea, Seoul
Ewha Womans University
United States, Boston
Brigham and Women's Hospital
Kim, Eun-bae
South Korea, Seoul
Ewha Womans University
South Korea, Chuncheon
Kangwon National University
Lobanov, Alexei V.
United States, Boston
Brigham and Women's Hospital
Yim, Sun-hee
United States, Boston
Brigham and Women's Hospital
Buffenstein, Rochelle B.
United States, San Antonio
University of Texas Health Science Center at San Antonio
Gladyshev, Vadim N.
South Korea, Seoul
Ewha Womans University
United States, Boston
Brigham and Women's Hospital
Statistics
Citations: 109
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1111/acel.12283
ISSN:
14749718
Research Areas
Cancer
Genetics And Genomics