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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Defining the genetic susceptibility to cervical neoplasia—A genome-wide association study
PLoS Genetics, Volume 13, No. 8, Article e1006866, Year 2017
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Description
A small percentage of women with cervical HPV infection progress to cervical neoplasia, and the risk factors determining progression are incompletely understood. We sought to define the genetic loci involved in cervical neoplasia and to assess its heritability using unbiased unrelated case/control statistical approaches. We demonstrated strong association of cervical neoplasia with risk and protective HLA haplotypes that are determined by the amino-acids carried at positions 13 and 71 in pocket 4 of HLA-DRB1 and position 156 in HLA-B. Furthermore, 36% (standard error 2.4%) of liability of HPV-associated cervical pre-cancer and cancer is determined by common genetic variants. Women in the highest 10% of genetic risk scores have approximately >7.1% risk, and those in the highest 5% have approximately >21.6% risk, of developing cervical neoplasia. Future studies should examine genetic risk prediction in assessing the risk of cervical neoplasia further, in combination with other screening methods. © 2017 Leo et al.
Authors & Co-Authors
Leo, Paul J.
Australia, Woolloongabba
Translational Research Institute Australia
Madeleine, Margaret M.
United States, Seattle
Fred Hutchinson Cancer Center
Wang, Sophia S.
United States, Duarte
City of Hope National Med Center
Schwartz, Stephen Marc
United States, Seattle
Fred Hutchinson Cancer Center
Pettersson-Kymmer, Ulrika
Sweden, Umea
Umeå Universitet
Hemminki, Kari
Germany, Heidelberg
German Cancer Research Center
Sweden, Lund
Lunds Universitet
Hallmans, Goran
Sweden, Umea
Umeå Universitet
Rader, Janet S.
United States, Milwaukee
Medical College of Wisconsin
Safaeian, Mahboobeh
United States, Rockville
National Cancer Institute Nci
Franco, Eduardo Luis Fabiano
Canada, Montreal
Université Mcgill
Coutlée, François
Canada, Montreal
University of Montreal
Ohlsson, Claes
Sweden, Gothenburg
Sahlgrenska Akademin
Sweden, Gothenburg
Göteborgs Universitet
Cortés, Adrián
Australia, Woolloongabba
Translational Research Institute Australia
Marshall, Mhairi S.
Australia, Woolloongabba
Translational Research Institute Australia
Cremin, Katie
Australia, Woolloongabba
Translational Research Institute Australia
Garland, Suzanne Marie
Australia, Melbourne
Royal Women's Hospital, Carlton
Australia, Melbourne
Murdoch Children's Research Institute
Tabrizi, Sepehr N.
Australia, Melbourne
Murdoch Children's Research Institute
Wentzensen, Nicolas A.
United States, Rockville
National Cancer Institute Nci
Sitas, F.
Australia, Woolloomooloo
Cancer Council Nsw
Australia, Sydney
The University of Sydney
Australia, Sydney
Unsw Sydney
Little, Julian H.
Canada, Ottawa
University of Ottawa
Hildesheim, Allan
United States, Rockville
National Cancer Institute Nci
Brown, Matthew A.
Australia, Woolloongabba
Translational Research Institute Australia
Statistics
Citations: 73
Authors: 22
Affiliations: 19
Identifiers
Doi:
10.1371/journal.pgen.1006866
ISSN:
15537390
Research Areas
Cancer
Genetics And Genomics
Participants Gender
Female