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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Reproductive strategies and population structure in Leishmania: Substantial amount of sex in Leishmania Viannia guyanensis
Molecular Ecology, Volume 20, No. 15, Year 2011
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Description
Leishmania species of the subgenus Viannia and especially Leishmania Viannia guyanensis are responsible for a large proportion of New World leishmaniasis cases. Since a recent publication on Leishmania Viannia braziliensis, the debate on the mode of reproduction of Leishmania parasites has been reopened. A predominant endogamic reproductive mode (mating with relatives), together with strong Wahlund effects (sampling of strains from heterogeneous subpopulations), was indeed evidenced. To determine whether this hypothesis can be generalized to other Leishmania Viannia species, we performed a population genetic study on 153 human strains of L. (V.) guyanensis from French Guiana based on 12 microsatellite loci. The results revealed important homozygosity and very modest linkage disequilibrium, which is in agreement with a high level of sexual recombination and substantial endogamy. These results also revealed a significant isolation by distance with relatively small neighbourhoods and hence substantial viscosity of Leishmania populations in French Guiana. These results are of epidemiological relevance and suggest a major role for natural hosts and/or vectors in parasite strain diffusion across the country as compared to human hosts. © 2011 Blackwell Publishing Ltd.
Authors & Co-Authors
Rougeron, Virginie
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Anne-Laure, Bañuls Laure
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Carme, Bernard
France, Cayenne
Centre Hospitalier de Cayenne
France, Pointe-a-pitre
Universite Des Antilles et de la Guyane
Simon, Stéphane
France, Pointe-a-pitre
Universite Des Antilles et de la Guyane
Couppié, Pierre
France, Pointe-a-pitre
Universite Des Antilles et de la Guyane
France, Cayenne
Centre Hospitalier de Cayenne
Nacher, Mathieu
France, Pointe-a-pitre
Universite Des Antilles et de la Guyane
Hide, Mallorie
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
de Mëeus, Thierry
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Burkina Faso, Bobo-dioulasso
Centre International de Recherche-developpement Sur Lelevage en Zone Subhumide, Bobo-dioulasso
Statistics
Citations: 40
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1111/j.1365-294X.2011.05162.x
ISSN:
09621083
e-ISSN:
1365294X
Research Areas
Genetics And Genomics
Sexual And Reproductive Health
Study Design
Cross Sectional Study