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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Burden of cadmium in early childhood: Longitudinal assessment of urinary cadmium in rural Bangladesh
Toxicology Letters, Volume 198, No. 1, Year 2010
Notification
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Description
Chronic cadmium exposure is associated with many adverse health effects in adults, but little is known about the scenario early in life. This study assessed cadmium exposure and body burden in young children, born to women with known cadmium exposure via rice. As part of our ongoing population-based, longitudinal study of health effects of early-life toxicants exposure in rural Bangladesh, we measured cadmium in urine of about 350 children at 1.5 and 5 years of age, and in 92 children at 3 months of age. Median cadmium concentrations in urine were 0.30, 0.16 and 0.30. μg/L at 3 months, 1.5 and 5 years of age, respectively (0.6. μg/L in mothers). Cadmium concentrations in infant's urine correlated with concentrations in maternal breast milk, saliva, and urine. As expected, concentrations in urine increased from 1.5 to 5 years of age. Rice (median 47. μg. Cd/kg) is most likely the main source of exposure. In conclusion, we found unexpectedly high cadmium exposure among children in rural Bangladesh. Urinary cadmium concentrations were particularly elevated at 3 months of age, indicating limited reabsorption and accumulation of cadmium in the kidneys, known to be the main site of cadmium burden in older children and adults. © 2010 Elsevier Ireland Ltd.
Authors & Co-Authors
Kippler, Maria J.
Sweden, Stockholm
Karolinska Institutet
Hamadani, Jena Derakhshani
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Tofail, Fahmida
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Moore, Sophie E.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Statistics
Citations: 64
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/j.toxlet.2010.04.029
ISSN:
03784274
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Participants Gender
Female