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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Efficacy of low-dose oral sulodexide in the management of diabetic nephropathy
Journal of Nephrology, Volume 23, No. 4, Year 2010
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Description
Background: Diabetic nephropathy (DN) is the single greatest cause of end-stage renal disease (ESRD). Without specific interventions, microalbuminuria (incipient nephropathy) gradually progresses to macroalbuminuria (overt nephropathy) within 10-15 years in about 80% of type 1 and 30% of type 2 diabetic patients, and to ESRD within further 20 years in about 75% and 20%, respectively. A primary alteration in DN consists of decreased concentration of glycosaminoglycans (GAGs) in the glomerular extracellular matrix. This evidence has prompted interest in using exogenous GAGs and specifically sulodexide in DN treatment. Patients and methods: In this uncontrolled multicenter study, diabetic patients with albumin excretion rate (AER) ≥30 mg/24 hours were treated with oral sulodexide 50 mg/day for 6 months, while receiving concomitant medication as required. Two hundred thirty-seven patients (54% males and 46% females, mean age 55 years, mean diabetes duration 11 years) were evaluated; 89% had type 2 and 11% type 1 diabetes mellitus, 67% microalbuminuria and 33% macroalbuminuria. Results: AER was significantly and progressively reduced during sulodexide treatment (p<0.0001): geometric mean after 3 and 6 months was 63.7% (95% confidence interval [95% CI], 59.3%-68.4%) and 42.7% (95% CI, 37.8%-48.2%) of baseline, respectively. The reduction was similar in type 1 and type 2 diabetes and was slightly greater in macroalbuminuric than in microalbuminuric patients. Blood pressure was slightly lowered, while fasting glucose and glycosylated hemoglobin were moderately reduced. Adverse effects were observed in 5.5% of patients, including gastrointestinal in 3.8%. Conclusions: Sulodexide therapy was shown to reduce AER in patients with DN. © 2010 Società Italiana di Nefrologia.
Authors & Co-Authors
Blouza, S.
Tunisia, Tunis
Institut National de Nutrition & Technologie Alimentaire
Dakhli, Sabeur
Tunisia, Tunis
Institut National de Nutrition & Technologie Alimentaire
Abid, Hafaoua
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Aissaoui, Mohamed
Unknown Affiliation
Ardhaoui, Ilhem
Unknown Affiliation
Abdallah, Néjib Ben
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Brahim, S. B.
Unknown Affiliation
Ghorbel, Imed Ben
Tunisia, Tunis
Hôpital la Rabta
Salem, N. B.
Unknown Affiliation
Béji, Soumaya
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Chamakhi, Saïd
Unknown Affiliation
Derbel, Adnene
Unknown Affiliation
Derouiche, F.
Unknown Affiliation
Djait, Faycal
Unknown Affiliation
Doghri, Taïeb
Unknown Affiliation
Fourti, Yamina
Unknown Affiliation
Gharbi, Faycel
Unknown Affiliation
Jellouli, Kamel
Unknown Affiliation
Jellazi, Nabil
Unknown Affiliation
Kamoun, Kamel
Unknown Affiliation
Khedher, Adel
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Létaief, Amel Omezzine
Tunisia, Sousse
Hopital Farhat Hached Sousse
Limam, Ridha
Unknown Affiliation
Mekaouer, Awatef
Unknown Affiliation
Miledi, Riadh
Unknown Affiliation
Nagati, Khemaies H.
Unknown Affiliation
Naouar, Meriem
Unknown Affiliation
Sellem, Sami
Unknown Affiliation
Tarzi, Hichem
Unknown Affiliation
Turki, Selma
Unknown Affiliation
Zidi, Bourni
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Militaire de Tunis
Achour, Abedellatif
Tunisia, Sousse
Chu Sahloul
Statistics
Citations: 32
Authors: 32
Affiliations: 6
Identifiers
ISSN:
11218428
e-ISSN:
17246059
Research Areas
Health System And Policy
Noncommunicable Diseases
Participants Gender
Female