Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
LEPR p.Q223R Polymorphism Influences Plasma Leptin Levels and Body Mass Index in Tunisian Obese Patients
Archives of Medical Research, Volume 40, No. 3, Year 2009
Notification
URL copied to clipboard!
Description
Background and Aims: The leptin receptor (LEPR) plays a crucial role in the regulation of body weight. Several common polymorphisms have been described in the human LEPR gene including the p.Q223R polymorphism (rs1137101). The association of this polymorphism with obesity or related metabolic phenotypes has been controversial. The aim of this study was to investigate the impact of the LEPR p.Q223R polymorphism on body mass index (BMI), plasma leptin and lipid parameters in a sample of the Tunisian population. Methods: The study included 391 obese patients and 302 normal weight subjects. LEPR p.Q223R genotypes were identified by the PCR-RFLP analysis. Results: Obese patients homozygous for RR genotype showed lower leptin levels than those with other genotypes (p = 0.005) adjusted for age, BMI and gender. Stratified analysis by gender revealed that obese male patients carrying the R allele showed significantly lower BMI (p = 0.007) and leptin levels (p = 0.037) than subjects homozygous for the Q allele. In obese women, the LEPR p.Q223R polymorphism was found associated with lower leptin concentrations (p = 0.05). After adjustment for age and BMI, the association between the LEPR variant and plasma leptin remained significant only within female patients (p = 0.027). A general linear model including leptin as dependant variable and age, BMI, menopausal status and genotype as covariates revealed that the LEPR p.Q223R polymorphism is independently associated with leptin levels in obese women (p = 0.026). Conclusions: Our findings suggest that the LEPR p.Q223R polymorphism influences plasma leptin levels and BMI in obese patients. © 2009 IMSS.
Authors & Co-Authors
Ben Ali, Samir
Tunisia, Tunis
Hôpital la Rabta
Kallel, Amani
Tunisia, Tunis
Hôpital la Rabta
Sédiri, Yousra
Tunisia, Tunis
Hôpital la Rabta
Ftouhi, Bochra
Tunisia, Tunis
Hôpital la Rabta
Feki, Moncef
Tunisia, Tunis
Hôpital la Rabta
Slimène, Hédia
Tunisia, Tunis
Hôpital la Rabta
Jemaa, Riadh
Tunisia, Tunis
Hôpital la Rabta
Kâabachi, Naziha
Tunisia, Tunis
Hôpital la Rabta
Statistics
Citations: 46
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1016/j.arcmed.2009.02.008
ISSN:
01884409
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Participants Gender
Male
Female