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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein
Cardiovascular Research, Volume 53, No. 4, Year 2002
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Description
Objective: Baseline concentrations of plasma C-reactive protein (CRP) are associated with coronary heart disease. Interleukin-6 (IL-6) regulates CRP gene expression; a promoter polymorphism (-174G/C) of the IL-6 gene has been shown to influence IL-6 transcription but the relationship between genotype at this polymorphism and circulating levels of inflammatory markers remains unclear. We hypothesised that plasma CRP would be a heritable phenotype that would be influenced by genotype at this polymorphism. Methods: We measured baseline plasma CRP and determined genotypes at the -174G/C polymorphism of the IL-6 gene in 588 members of 98 nuclear families. The heritability of plasma CRP and the association of plasma CRP with genotype were determined using variance components methods. Results: Baseline CRP levels were highly heritable (h2=0.39, P<0.0000001). Presence of the -174C allele was associated with higher baseline CRP levels, both in the whole population (P=0.01), and in the founders only (n=128, P=0.001). Family-based analyses confirmed the association (P=0.02) suggesting that it arises from chromosomal proximity or identity of the typed polymorphism with a genetic variant influencing baseline CRP levels. Conclusions: Baseline plasma CRP is a significantly heritable cardiovascular risk factor. Levels are associated with genotype at the -174G/C polymorphism of the IL-6 gene. © 2002 Elsevier Science B.V. All rights reserved.
Authors & Co-Authors
Vickers, Mark Adrian
United Kingdom, Aberdeen
University of Aberdeen
Green, Fiona R.
United Kingdom, Oxford
University of Oxford
Mayosi, Bongani M.
United Kingdom, Oxford
University of Oxford
Julier, Cécile
France, Paris
Institut Pasteur, Paris
Lathrop, Mark G.
France, Evry
Centre National de Recherche en Génomique Humaine
Ratcliffe, Peter J.
United Kingdom, Oxford
University of Oxford
Watkins, Hugh C.
United Kingdom, Oxford
University of Oxford
Keavney, Bernard D.
United Kingdom, Newcastle
Newcastle University
United Kingdom, Newcastle
International Centre for Life
Statistics
Citations: 270
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1016/S0008-6363(01)00534-X
ISSN:
00086363
Research Areas
Cancer
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study