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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Predictors of stunting, wasting and underweight among Tanzanian children born to HIV-infected women
European Journal of Clinical Nutrition, Volume 66, No. 11, Year 2012
Notification
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Description
Background/Objectives:Children born to human immunodeficiency virus (HIV)-infected women are susceptible to undernutrition, but modifiable risk factors and the time course of the development of undernutrition have not been well characterized. The objective of this study was to identify maternal, socioeconomic and child characteristics that are associated with stunting, wasting and underweight among Tanzanian children born to HIV-infected mothers, followed from 6 weeks of age for 24 months.Subjects/Methods:Maternal and socioeconomic characteristics were recorded during pregnancy, data pertaining to the infants birth were collected immediately after delivery, morbidity histories and anthropometric measurements were performed monthly. Multivariate Cox proportional hazards methods were used to assess the association between potential predictors and the time to first episode of stunting, wasting and underweight.Results:A total of 2387 infants (54.0% male) were enrolled and followed for a median duration of 21.2 months. The respective prevalence of prematurity (37 weeks) and low birth weight (2500 g) was 15.2% and 7.0%; 11.3% of infants were HIV-positive at 6 weeks. Median time to first episode of stunting, wasting and underweight was 8.7, 7.2 and 7.0 months, respectively. Low maternal education, few household possessions, low infant birth weight, child HIV infection and male sex were all independent predictors of stunting, wasting and underweight. In addition, preterm infants were more likely to become wasted and underweight, whereas those with a low Apgar score at birth were more likely to become stunted.Conclusions:Interventions to improve maternal education and nutritional status, reduce mother-to-child transmission of HIV, and increase birth weight may lower the risk of undernutrition among children born to HIV-infected women. © 2012 Macmillan Publishers Limited.
Authors & Co-Authors
McDonald, Christine M.
United States, Boston
Harvard T.h. Chan School of Public Health
Kupka, Roland
United States, Boston
Harvard T.h. Chan School of Public Health
United States, New York
Unicef
Manji, Karim Premji
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Okuma, James O.
United States, Boston
Harvard T.h. Chan School of Public Health
Bosch, Ronald J.
United States, Boston
Harvard T.h. Chan School of Public Health
Aboud, Said
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Kisenge, Rodrick R.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Spiegelman, Donna L.
United States, Boston
Harvard T.h. Chan School of Public Health
Fawzi, Wafaie W.
United States, Boston
Harvard T.h. Chan School of Public Health
Duggan, Christopher P.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Boston Children's Hospital
Statistics
Citations: 58
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1038/ejcn.2012.136
ISSN:
09543007
Research Areas
Food Security
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Participants Gender
Male
Female