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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Expression of Epstein–Barr virus replicative proteins in aids‐related non‐Hodgkin's lymphoma cells
The Journal of Pathology, Volume 165, No. 4, Year 1991
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Description
Epstein‐Barr virus (EBV) infection in lymphoproliferative lesions has been assumed to be strictly latent. In order to investigate the possible occurrence of EBV replication in AIDS‐related lymphoma (ARL) cells, we studied 13 cases by immunohistology using monoclonal antibodies to the EBV‐encoded switch‐protein BZLF1, early antigens (EAs), late replicative proteins [virus capsid antigens (VCAs) and membrane antigens (MAs)], and to the latent proteins EB nuclear antigen 2 (EBNA 2) and latent membrane protein (LMP). EBV genomes were detected by in situ hybridization. EBV genomes and/or gene products were demonstrated in ten cases, including all immunoblast‐rich lymphomas, two Burkitts lymphomas, and a T‐cell anaplastic large‐cell lymphoma. The BZLF1 protein, which disrupts latency in B cells, was identified in six (60 per cent), and EAs in four (40 per cent) of the EBV‐positive ARL. Only one lymphoma (10 per cent) expressed VCAs and MAs. EBNA 2 and LMP were detected in three (30 per cent) and eight (80 per cent) of EBV‐positive cases, respectively. EBV DNA was detected in lymphoma cells in 7 of 12 (58 per cent) cases. The most important finding of this study was frequent spontaneous activation of latent EBV in ARL. Production of complete virus, however, was either aborted, or tumour cells expressing late productive cycle proteins (VCA, MA) were rapidly cleared from tissues. It is suggested that host factors that normally inhibit replication of EBV are deficient in AIDS patients. Copyright © 1991 John Wiley & Sons, Ltd.
Authors & Co-Authors
Pallesen, Gorm
Denmark, Aarhus
Aarhus Universitetshospital
Denmark, Copenhagen
Rigshospitalet
United Kingdom, London
Cancer Research uk
Rowe, Martin
Denmark, Aarhus
Aarhus Universitetshospital
Denmark, Copenhagen
Rigshospitalet
United Kingdom, London
Cancer Research uk
Lisse, Ida Maria
Denmark, Aarhus
Aarhus Universitetshospital
Denmark, Copenhagen
Rigshospitalet
United Kingdom, London
Cancer Research uk
Ralfkiær, Elisabeth Methner
Denmark, Aarhus
Aarhus Universitetshospital
Denmark, Copenhagen
Rigshospitalet
United Kingdom, London
Cancer Research uk
Young, Lawrence S.
Denmark, Aarhus
Aarhus Universitetshospital
Denmark, Copenhagen
Rigshospitalet
United Kingdom, London
Cancer Research uk
Statistics
Citations: 113
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1002/path.1711650404
ISSN:
00223417
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases