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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Increased risk of early measles in infants of human immunodeficiency virus type 1-seropositive mothers
Journal of Infectious Diseases, Volume 165, No. 2, Year 1992
Notification
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Description
An increase in illness due to measles is one of the potential consequences of the human immunodeficiency virus (HIV) epidemic in Africa. During a study of perinatal HIV transmission conducted in Kenya, the risk of acquiring measles before vaccination (9 months of age) was found to be 3.8 times higher in infants born to HIV-seropositive mothers than in control infants (10 [9%] of 109 vs. 5 [3%] of 194 infants; P =.02; odds ratio, 3.8; 95% confidence interval, 1.2-13.2). The majority of infants who developed measles in this study had significant sequelae related to their measles infection. The increased risk of measles appeared to be related to relatively lower anti-measles antibody titers detected in cord blood samples of affected infants born to HIV-sero- positive mothers. However, 94% of all infants were susceptible to measles on the basis of ELISA testing at age 6 months regardless of maternal HIV serology. These observations highlight the need for improved measles vaccination strategies in Africa and for studies to delineate the effects of HIV infection on the incidence, presentation, and sequelae of childhood infectious illnesses. © 1992 Oxford University Press.
Authors & Co-Authors
Embreé, Joanne E.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
United Kingdom, London
Ucl Medical School
United States, Seattle
University of Washington
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Datta, Pratibha
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
United Kingdom, London
Ucl Medical School
United States, Seattle
University of Washington
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Stackiw, Walter
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
United Kingdom, London
Ucl Medical School
United States, Seattle
University of Washington
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Sekla, Leila H.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
United Kingdom, London
Ucl Medical School
United States, Seattle
University of Washington
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Braddick, Michael R.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
United Kingdom, London
Ucl Medical School
United States, Seattle
University of Washington
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Kreiss, Joan K.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
United Kingdom, London
Ucl Medical School
United States, Seattle
University of Washington
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Pamba, Hannington O.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
United Kingdom, London
Ucl Medical School
United States, Seattle
University of Washington
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Wamola, Isaac A.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
United Kingdom, London
Ucl Medical School
United States, Seattle
University of Washington
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Ndinya, J. O.A.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
United Kingdom, London
Ucl Medical School
United States, Seattle
University of Washington
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Law, Barbara J.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
United Kingdom, London
Ucl Medical School
United States, Seattle
University of Washington
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Piot, Peter K.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
United Kingdom, London
Ucl Medical School
United States, Seattle
University of Washington
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Holmes, King K.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
United Kingdom, London
Ucl Medical School
United States, Seattle
University of Washington
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Plummer, Francis Allan
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
United Kingdom, London
Ucl Medical School
United States, Seattle
University of Washington
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Statistics
Citations: 85
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1093/infdis/165.2.262
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Case-Control Study
Study Locations
Kenya