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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The effects of circumcision on the penis microbiome
PLoS ONE, Volume 5, No. 1, Article e8422, Year 2010
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Description
Background: Circumcision is associated with significant reductions in HIV, HSV-2 and HPV infections among men and significant reductions in bacterial vaginosis among their female partners. Methodology/Principal Findings: We assessed the penile (coronal sulci) microbiota in 12 HIV-negative Ugandan men before and after circumcision. Microbiota were characterized using sequence-tagged 16S rRNA gene pyrosequencing targeting the V3 - V4 hypervariable regions. Taxonomic classification was performed using the RDP Naïve Bayesian Classifier. Among the 42 unique bacterial families identified, Pseudomonadaceae and Oxalobactericeae were the most abundant irrespective of circumcision status. Circumcision was associated with a significant change in the overall microbiota (PerMANOVA p = 0.007) and with a significant decrease in putative anaerobic bacterial families (Wilcoxon Signed-Rank test p = 0.014). Specifically, two families - Clostridiales Family XI (p = 0.006) and Prevotellaceae (p = 0.006) - were uniquely abundant before circumcision. Within these families we identified a number of anaerobic genera previously associated with bacterial vaginosis including: Anaerococcus spp., Finegoldia spp., Peptoniphilus spp., and Prevotella spp. Conclusions/Significance: The anoxic microenvironment of the subpreputial space may support pro-inflammatory anaerobes that can activate Langerhans cells to present HIV to CD4 cells in draining lymph nodes. Thus, the reduction in putative anaerobic bacteria after circumcision may play a role in protection from HIV and other sexually transmitted diseases. © 2010 Price et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2798966/bin/pone.0008422.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2798966/bin/pone.0008422.s002.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC2798966/bin/pone.0008422.s003.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC2798966/bin/pone.0008422.s004.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC2798966/bin/pone.0008422.s005.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC2798966/bin/pone.0008422.s006.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2798966/bin/pone.0008422.s007.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2798966/bin/pone.0008422.s008.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2798966/bin/pone.0008422.s009.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2798966/bin/pone.0008422.s010.doc
Authors & Co-Authors
Price, Lance L. B.
United States, Phoenix
Translational Genomics Research Institute
Liu, Cindy Meng Hsin
United States, Phoenix
Translational Genomics Research Institute
United States, Flagstaff
Northern Arizona University
Johnson, Kristine E.
United States, Baltimore
Johns Hopkins Medical Institutions
Aziz, Maliha
United States, Phoenix
Translational Genomics Research Institute
Lau, Matthew K.
United States, Flagstaff
Northern Arizona University
Bowers, Jolene R.
United States, Phoenix
Translational Genomics Research Institute
Ravel, Jacques
United States, Baltimore
University of Maryland School of Medicine
Keim, Paul S.
United States, Phoenix
Translational Genomics Research Institute
United States, Flagstaff
Northern Arizona University
Serwadda, David Musoke
Uganda, Kampala
Makerere University
Wawer, Maria J.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Gray, Ronald H.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Statistics
Citations: 233
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0008422
e-ISSN:
19326203
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Participants Gender
Male
Female