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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Evaluation of the possible contribution of antioxidants administration in metabolic syndrome
Current Pharmaceutical Design, Volume 17, No. 33, Year 2011
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Description
The metabolic syndrome (MetS) is common, and its associated risk burdens of diabetes and cardiovascular disease (CVD) are a major public health problem. The hypothesis that main constituent parameters of the MetS share common pathophysiologic mechanisms provides a conceptual framework for the future research. Exercise and weight loss can prevent insulin resistance and reduce the risk of diseases associated with the MetS. Interrupting intracellular and extracellular reactive oxygen species (ROS) overproduction could also contribute to normalizing the activation of metabolic pathways leading to the onset of diabetes, endothelial dysfunction, and cardiovascular (CV) complications. On the other hand, it is difficult to counteract the development of CV complications by using conventional antioxidants. Indeed, interest has focused on strategies that enhance the removal of ROS using either antioxidants or drugs that enhance endogenous antioxidant defense. Although these strategies have been effective in laboratory experiments, several clinical trials have shown that they do not reduce CV events, and in some cases antioxidants have actually worsened the outcome. More research is needed in this field. © 2011 Bentham Science Publishers.
Authors & Co-Authors
Haidara, M. A.
Egypt, Cairo
Faculty of Medicine
Mikhailidis, D. P.
United Kingdom, London
Ucl Medical School
Yassin, Hanaa Zaki
Egypt, Cairo
Faculty of Medicine
Dobutović, Branislava D.
Serbia, Belgrade
Institut za Nuklearne Nauke Vinca
Smiljanić, Katarina T.
Serbia, Belgrade
Institut za Nuklearne Nauke Vinca
Soskić, Sanja S.
Serbia, Belgrade
Institut za Nuklearne Nauke Vinca
Mousa, Shaker A.
United States, Albany
Albany College of Pharmacy and Health Sciences
Rizzo, Manfredi
Italy, Palermo
Università Degli Studi Di Palermo
Italy, Palermo
Euro-mediterranean Institute of Science and Technology
Isenovic, R. Esma
Serbia, Belgrade
Institut za Nuklearne Nauke Vinca
Statistics
Citations: 20
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.2174/138161211798220882
ISSN:
13816128
e-ISSN:
18734286
Research Areas
Noncommunicable Diseases