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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Methodological aspects of clinical trials in tinnitus: A proposal for an international standard
Journal of Psychosomatic Research, Volume 73, No. 2, Year 2012
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Description
Chronic tinnitus is a common condition with a high burden of disease. While many different treatments are used in clinical practice, the evidence for the efficacy of these treatments is low and the variance of treatment response between individuals is high. This is most likely due to the great heterogeneity of tinnitus with respect to clinical features as well as underlying pathophysiological mechanisms. There is a clear need to find effective treatment options in tinnitus, however, clinical trials differ substantially with respect to methodological quality and design. Consequently, the conclusions that can be derived from these studies are limited and jeopardize comparison between studies. Here, we discuss our view of the most important aspects of trial design in clinical studies in tinnitus and make suggestions for an international methodological standard in tinnitus trials. We hope that the proposed methodological standard will stimulate scientific discussion and will help to improve the quality of trials in tinnitus. © 2012 Elsevier Inc.
Authors & Co-Authors
Landgrebe, Michael
Unknown Affiliation
Azevedo, Andréia
Unknown Affiliation
Baguley, David M.
Unknown Affiliation
Bauer, Carol
Unknown Affiliation
Cacace, Anthony
Unknown Affiliation
Coelho, Claudia
Unknown Affiliation
Dornhoffer, John
Unknown Affiliation
Figueiredo, Ricardo
Unknown Affiliation
Flor, Herta
Unknown Affiliation
Hajak, Göran
Unknown Affiliation
van de Heyning, Paul Henry
Unknown Affiliation
Hiller, Wolfgang
Unknown Affiliation
Khedr, Eman M.
Unknown Affiliation
Kleinjung, Tobias
Unknown Affiliation
Koller, Michael
Unknown Affiliation
Láinez-Andrés, José Miguel
Unknown Affiliation
Londero, Alain
Unknown Affiliation
Martin, William H.
Unknown Affiliation
Mennemeier, Mark
Unknown Affiliation
Piccirillo, Jay F.
Unknown Affiliation
De Ridder, Dirk D.
Unknown Affiliation
Rupprecht, Rainer
Unknown Affiliation
Searchfield, Grant
Unknown Affiliation
Vanneste, Sven
Unknown Affiliation
Zeman, Florian
Unknown Affiliation
Langguth, Berthold
Unknown Affiliation
Statistics
Citations: 156
Authors: 26
Affiliations: 18
Identifiers
Doi:
10.1016/j.jpsychores.2012.05.002
ISSN:
00223999
Research Areas
Genetics And Genomics