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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2
Journal of Clinical Investigation, Volume 132, No. 7, Article e157124, Year 2022
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Description
BACKGROUND. Although recent epidemiological data suggest that pneumococci may contribute to the risk of SARS-CoV-2 disease, cases of coinfection with Streptococcus pneumoniae in patients with coronavirus disease 2019 (COVID-19) during hospitalization have been reported infrequently. This apparent contradiction may be explained by interactions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and pneumococci in the upper airway, resulting in the escape of SARSCoV-2 from protective host immune responses. METHODS. Here, we investigated the relationship of these 2 respiratory pathogens in 2 distinct cohorts of health care workers with asymptomatic or mildly symptomatic SARS-CoV-2 infection identified by systematic screening and patients with moderate to severe disease who presented to the hospital. We assessed the effect of coinfection on host antibody, cellular, and inflammatory responses to the virus. RESULTS. In both cohorts, pneumococcal colonization was associated with diminished antiviral immune responses, which primarily affected mucosal IgA levels among individuals with mild or asymptomatic infection and cellular memory responses in infected patients. CONCLUSION. Our findings suggest that S. pneumoniae impair host immunity to SARS-CoV-2 and raise the question of whether pneumococcal carriage also enables immune escape of other respiratory viruses and facilitates reinfection. Copyright: © 2022, Mitsi et al
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8970672/bin/jci-132-157124-s088.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8970672/bin/jci-132-157124-s089.pdf
Authors & Co-Authors
Mitsi, Elena
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Jesus, Reiné J
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Urban, Britta Christina
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Solórzano, Carla
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Nikolaou, Elissavet
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Hyder-Wright, Angela D.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Pojar, Sherin
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Howard, Ashleigh
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Hitchins, Lisa
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Farrar, Madlen C.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Liatsikos, Konstantinos
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Collins, Andrea M.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
United Kingdom, Liverpool
University of Liverpool
Walker, Naomi F.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
United Kingdom, Liverpool
University of Liverpool
Hill, Helen C.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
German, Esther L.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Cheliotis, Katerina S.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Byrne, Rachel L.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Williams, Christopher Thomas
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Cubas-Atienzar, Ana Isabel
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Fletcher, Tom E.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Adams, E. R.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Draper, Simon J.
United Kingdom, Oxford
The Jenner Institute
Pulido, David
United Kingdom, Oxford
The Jenner Institute
Beavon, Rohini
United States, Collegeville
Pfizer Vaccines
Theilacker, Christian
United States, Collegeville
Pfizer Vaccines
Begier, Elizabeth M.
United States, Collegeville
Pfizer Vaccines
Jódar, Luis
United States, Collegeville
Pfizer Vaccines
Gessner, Bradford D.
United States, Collegeville
Pfizer Vaccines
Ferreira, Daniela Mulari
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Statistics
Citations: 24
Authors: 29
Affiliations: 4
Identifiers
Doi:
10.1172/JCI157124
ISSN:
00219738
Research Areas
Covid
Health System And Policy
Study Design
Cohort Study