The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches
Cell Reports, Volume 29, No. 7, Year 2019
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PTEN globally suppresses growth in multiple cell types and inhibits neuronal axon growth and branching. Brosig et al. describe a mechanism for developing neurons to inhibit PTEN function by upregulating PRG2 in the axon. Although the overall growth capacity of neurons remains constant, PRG2 redirects growth to axon branches.