Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Determinants of the maternal 25-Hydroxyvitamin D response to Vitamin D supplementation during pregnancy
Journal of Clinical Endocrinology and Metabolism, Volume 101, No. 12, Year 2016
Notification
URL copied to clipboard!
Description
Context: Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin D (25(OH)D) response. Objective: We assessed which maternal and environmental characteristics were associated with 25(OH)D after supplementation with cholecalciferol. Design: Within-randomization-group analysis of participants in the Maternal Vitamin D Osteoporosis Study trial of vitamin D supplementation in pregnancy. Setting: Hospital antenatal clinics. Participants:Atotal of 829 pregnantwomen(422 placebo, 407 cholecalciferol). At 14 and 34 weeks of gestation, maternal anthropometry, health, and lifestyle were assessed and 25(OH)D measured. Compliance was determined using pill counts at 19 and 34 weeks. Interventions: 1000 IU/d of cholecalciferol or matched placebo from 14 weeks of gestation until delivery. Main Outcome Measure: 25(OH)D at 34 weeks, measured in a single batch (Diasorin Liaison). Results: 25(OH)D at 34 weeks of gestation was higher in the women randomized to vitamin D (mean [SD], 67.7 [21.3] nmol/L) compared with placebo (43.1 [22.5] nmol/L; P < .001). In women randomized to cholecalciferol, higher pregnancy weight gain from 14 to 34 weeks of gestation (kg) (β=-0.81 [95% confidence interval -1.39, -0.22]), lower compliance with study medication (%) (β=-0.28 [-0.072, -0.48]), lower early pregnancy 25(OH)D (nmol/L) (β=-0.28 [0.16, 0.40]), and delivery in the winter vs the summer (β=-10.5 [-6.4,-14.6]) were independently associated with lower 25(OH)D at 34 weeks of gestation. Conclusions: Women who gained more weight during pregnancy had lower 25(OH)D in early pregnancy and delivered in winter achieved a lower 25(OH)D in late pregnancy when supplemented with 1000 IU/d cholecalciferol. Future studies should aim to determine appropriate doses to enable consistent repletion of 25(OH)D during pregnancy. © 2016 by the Endocrine Society.
Authors & Co-Authors
Harvey, Nicholas C.W.
United Kingdom, Southampton
Southampton General Hospital
United Kingdom, Royston
National Institute for Health and Care Research
Cooper, Cyrus C.
United Kingdom, Southampton
Southampton General Hospital
United Kingdom, Royston
National Institute for Health and Care Research
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
D'Angelo, Stefania
United Kingdom, Southampton
Southampton General Hospital
Crozier, Sarah R.
United Kingdom, Southampton
Southampton General Hospital
Inskip, Hazel M.
United Kingdom, Southampton
Southampton General Hospital
Schoenmakers, Inez
United Kingdom, Cambridge
Mrc Human Nutrition Research
United Kingdom, Norwich
University of East Anglia
Prentice, Ann M.
United Kingdom, Cambridge
Mrc Human Nutrition Research
Arden, Nigel K.
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Bishop, Nick J.
United Kingdom, Sheffield
Sheffield Children's Hospital
Carr, Andrew Jonathan
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Dennison, Elaine Margaret
United Kingdom, Southampton
Southampton General Hospital
Eastell, R.
United Kingdom, Sheffield
The University of Sheffield
Fräser, Robert B.
United Kingdom, Wakefield
Nhs England
Godfrey, Keith M.
United Kingdom, Southampton
Southampton General Hospital
United Kingdom, Royston
National Institute for Health and Care Research
Kennedy, Stephen H.
United Kingdom, Oxford
John Radcliffe Hospital
Mughal, M. Z.
United Kingdom, Manchester
Royal Manchester Children's Hospital
Papageorghiou, Aris T.
United Kingdom, Oxford
John Radcliffe Hospital
Reid, David M.
United Kingdom, Aberdeen
University of Aberdeen
Robinson, Sîan M.
United Kingdom, Southampton
Southampton General Hospital
Javaid, Muhammad Kassim
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Statistics
Citations: 42
Authors: 20
Affiliations: 12
Identifiers
Doi:
10.1210/jc.2016-2869
ISSN:
0021972X
Research Areas
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Participants Gender
Female