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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
Cell Reports, Volume 37, No. 7, Article 110020, Year 2021
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Description
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types. © 2021 The Author(s)
Authors & Co-Authors
Arthur, Timothy D.
United States, La Jolla
University of California, San Diego
Frazer, Kelly A.
United States, La Jolla
University of California, San Diego
Neale, Benjamin M.
Unknown Affiliation
Daly, Mark J.
Unknown Affiliation
Ganna, Andrea
Unknown Affiliation
Stevens, Christine R.
Unknown Affiliation
Pathak, Gita A.
Unknown Affiliation
Polimanti, Renato
Unknown Affiliation
Pirinen, Matti J.
Unknown Affiliation
Veerapen, Kumar
Unknown Affiliation
Wolford, Brooke N.
Unknown Affiliation
Nguyen, Huy
Unknown Affiliation
Stevens, Christine R.
Unknown Affiliation
Chwiałkowska, Karolina
Unknown Affiliation
Hayward, Caroline
Unknown Affiliation
Richmond, Anne
Unknown Affiliation
Campbell, Archie M.
Unknown Affiliation
Glessner, Joseph T.
Unknown Affiliation
Hakonarson, Hakon
Unknown Affiliation
Porteous, David John
Unknown Affiliation
Below, Jennifer E.
Unknown Affiliation
North, Kari E.
Unknown Affiliation
McCormick, Joseph B.
Unknown Affiliation
Timmers, Paul R.H.J.
Unknown Affiliation
Wilson, James F.
Unknown Affiliation
Tenesa, Albert
Unknown Affiliation
Kerr, Shona M.
Unknown Affiliation
Sobh, Ali
Unknown Affiliation
Eltoukhy, Madonna M.
Unknown Affiliation
Yassen, Amr Mohamed
Unknown Affiliation
Hegazy, Mohamed Abdel Fattah
Unknown Affiliation
Okasha, Kamal M.
Unknown Affiliation
Eid, Mohammed A.
Unknown Affiliation
Shahin, Doaa Abd ELhaliem
Unknown Affiliation
El-Sherbiny, Yasser M.
Unknown Affiliation
Elhadidy, Tamer
Unknown Affiliation
Abd Elghafar, Mohamed S.
Unknown Affiliation
El-Jawhari, Jehan J.
Unknown Affiliation
Elnagdy, Marwa H.
Unknown Affiliation
Torky, Mohamed S.
Unknown Affiliation
El-Shanshory, Mohammed Ramadan
Unknown Affiliation
Batini, Chiara
Unknown Affiliation
Lee, Paul H.
Unknown Affiliation
Shrine, Nick R.G.
Unknown Affiliation
Tobin, Martin D.
Unknown Affiliation
John, Catherine
Unknown Affiliation
Packer, Richard J.
Unknown Affiliation
Free, Robert C.
Unknown Affiliation
Wain, Louise V.
Unknown Affiliation
Hollox, Edward J.
Unknown Affiliation
Niavarani, Ahmadreza R.
Unknown Affiliation
Shotelersuk, Vorasuk
Unknown Affiliation
Pongpanich, Monnat
Unknown Affiliation
Jantarabenjakul, Watsamon
Unknown Affiliation
Puthanakit, Thanyawee
Unknown Affiliation
Sodsai, Pimpayao
Unknown Affiliation
Brumpton, Ben M.
Unknown Affiliation
Hveem, Kristian
Unknown Affiliation
Willer, Cristen J.
Unknown Affiliation
Åsvold, Bjørn Olav
Unknown Affiliation
Abedalthagafi, Malak
Unknown Affiliation
Alaamery, Manal A.
Unknown Affiliation
Alqahtani, Saleh A.
Unknown Affiliation
Al Harthi, Fawz S.
Unknown Affiliation
Alsolm, Ebtehal A.
Unknown Affiliation
Safieh, Leen Abu
Unknown Affiliation
Alqubaishi, Fatimah Abdulrahman
Unknown Affiliation
Mangul, Serghei
Unknown Affiliation
Alshareef, Abdulraheem
Unknown Affiliation
Almutairi, Mansour S.
Unknown Affiliation
Aljawini, Nora
Unknown Affiliation
Arabi, Yaseen M.
Unknown Affiliation
Mahmoud, Ebrahim Sabri
Unknown Affiliation
Alahmadey, Ziab Zakey
Unknown Affiliation
Albakri, Jehad K.
Unknown Affiliation
Suliman, Bandar Ali
Unknown Affiliation
Hasanato, Rana Muhammed W.
Unknown Affiliation
Alghamdi, Jahad
Unknown Affiliation
AlJohani, Sameera M.
Unknown Affiliation
Al-Afghani, Hani M.
Unknown Affiliation
Alrashed, May Mohammed
Unknown Affiliation
Almalki, Faisal Turki
Unknown Affiliation
Almohammed, Iman
Unknown Affiliation
Albader, Anoud Abdulmalik
Unknown Affiliation
Massadeh, Salam
Unknown Affiliation
AlMalik, Abdulaziz M.
Unknown Affiliation
AlOtaibi, Sara S.
Unknown Affiliation
Alghamdi, Bader J.
Unknown Affiliation
Jung, Junghyun
Unknown Affiliation
Fawzy, Mohammad S.
Unknown Affiliation
Magnus, Per Minor
Unknown Affiliation
Harris, Jennifer Ruth
Unknown Affiliation
Mangino, Massimo
Unknown Affiliation
Spector, Tim David
Unknown Affiliation
Przychodzen, Bartlomiej P.
Unknown Affiliation
Fernández-Cádenas, Israel
Unknown Affiliation
Cullell, Natalia
Unknown Affiliation
Muiño, Elena
Unknown Affiliation
Carcel-Marquez, Jara
Unknown Affiliation
Iglesias, Lara Lloret
Unknown Affiliation
Planas, Anna M.
Unknown Affiliation
Bedini, José Luis
Unknown Affiliation
Lozano, Francisco
Unknown Affiliation
Gómez, Juan M.
Unknown Affiliation
Coto, Eliécer
Unknown Affiliation
García Clemente, M. M.
Unknown Affiliation
Dalmau, David
Unknown Affiliation
Arranz, María Jesús
Unknown Affiliation
Colobran Oriol, Roger
Unknown Affiliation
Martín-Nalda, Andrea
Unknown Affiliation
Segura, Tomás
Unknown Affiliation
Serrano-Heras, Gemma
Unknown Affiliation
Martí-Fábregas, Joan
Unknown Affiliation
Garcia-Madrona, Sebastián
Unknown Affiliation
Chasman, Daniel I.
Unknown Affiliation
Buring, Julie E.
Unknown Affiliation
Ridker, Paul M.
Unknown Affiliation
Sesso, Howard D.
Unknown Affiliation
Manson, Jo Ann E.
Unknown Affiliation
Chang, Xiao
Unknown Affiliation
Håkonarson, Håkon H.
Unknown Affiliation
Campbell, Archie I.
Unknown Affiliation
Medina-Gõmez, Carolina
Unknown Affiliation
Uitterlinden, André G.
Unknown Affiliation
Ikram, Mohammad Arfan
Unknown Affiliation
Kristiansson, Kati
Unknown Affiliation
Perola, Markus
Unknown Affiliation
Kivinen, Katja J.
Unknown Affiliation
Palotie, Aarno V.
Unknown Affiliation
Ripatti, Samuli O.
Unknown Affiliation
Ruotsalainen, Sanni E.
Unknown Affiliation
Kaunisto, Mari Anneli
Unknown Affiliation
Butler-Laporte, Guillaume
Unknown Affiliation
Forgetta, Vincenzo
Unknown Affiliation
Morrison, David R.
Unknown Affiliation
Schurr, Erwin
Unknown Affiliation
Oliveira, Maureen
Unknown Affiliation
Brenner, Bluma G.
Unknown Affiliation
Lepage, Pierre
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Ragoussis, Ioannis
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Chassé, Michaël
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Kaufmann, Daniel Elias
Unknown Affiliation
Lathrop, Mark G.
Unknown Affiliation
Mooser, Vincent E.
Unknown Affiliation
Li, Rui
Unknown Affiliation
Rahmouni, Souad
Unknown Affiliation
Georges, Michel
Unknown Affiliation
Moutschen, Michel
Unknown Affiliation
Misset, Benoıˆt Y.
Unknown Affiliation
Darcis, Gilles
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Guiot, Julien
Unknown Affiliation
Beguin, Yves
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Malaise, Olivier
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Huynen, Pascale
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Léonard, Philippe
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Daya, Michelle
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Rafaels, Nicholas M.
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Crooks, Kristy R.C.
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Barnes, Kathleen C.
Unknown Affiliation
Chavan, Sameer
Unknown Affiliation
Läll, Kristi
Unknown Affiliation
Mägi, Reedik
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Esko, Tönu
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Milani, Lili A.
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Metspalu, Andres H.
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Laane, Edward
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Peterson, Pärt
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Kisand, Kai E.
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Starkopf, Joel
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Bochud, Pierre Yves
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Rivolta, Carlo
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Bibert, Stephanie
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Quinodoz, Mathieu
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Albrich, Werner Christian
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Suh, Noémie
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Neofytos, DIonysios
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de Cid, Rafael
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Galván-Femenía, Iván
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Carreras, Anna
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Cortés, Beatriz
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Sumoy, Lauro
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Moreno, Victor R.
Unknown Affiliation
Garcia-Aymerich, Judith M.
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Dobaño, Carlota
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Renieri, A.
Unknown Affiliation
Mari, Francesca
Unknown Affiliation
Fallerini, Chiara
Unknown Affiliation
Fava, Francesca
Unknown Affiliation
Valentino, Floriana
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Mencarelli, Maria Antonietta
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Busani, Stefano
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Bruno, R.
Unknown Affiliation
Vecchia, Marco
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Furini, Simone
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Castelli, Francesco
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Quiròs-Roldan, Eugenia
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Rusconi, Stefano
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Siano, Matteo
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Montagnani, Francesca
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Fabbiani, Massimiliano
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Rossetti, Barbara
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Bargagli, Elena
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Cameli, Paolo
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Bennett, David Alan
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Mazzei, M. A.
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Conticini, Edoardo
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Cantarini, Luca
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Frediani, Bruno
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d'Arminio-Monforte, Antonella
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Girardis, Massimo
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Cossarizza, Andrea
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Antinori, Andrea
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Vergori, Alessandra
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Riva, Agostino
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Parisi, Saverio Giuseppe
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Della Monica, Matteo
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Piscopo, Carmelo
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Russo, Roberta
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Andolfo, Immacolata
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Iolascon, Achille
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Fiorentino, Giuseppe
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Carella, Massimo
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Castori, Marco
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Merla, Giuseppe
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Aucella, Filippo
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Bassetti, Matteo
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Di Biagio, Antonio
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Coviello, Domenico A.
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Mussini, Cristina
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CROTTI, L.
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Rizzi, Marco
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Maggiolo, Franco
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Ripamonti, Diego
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La Rovere, Maria Teresa
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Raimondi, Francesco
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Filippo, Biscarini
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Stella, Alessandra
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Parati, Gianfranco
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Ravaglia, Sabrina
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Artuso, Rosangela
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Catena, Emanuele
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Colombo, Riccardo
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Ferri, Claudio
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Tumbarello, Mario
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Segala, Francesco Vladimiro
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Tiseo, Giusy
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Falcone, Marco
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Smith, Albert Vernon
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Justice, Anne E.
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Josyula, Navya Shilpa
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Kosmicki, Jack A.
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Ferreira, Manuel Allen Revez
Unknown Affiliation
Leader, Joseph B.
Unknown Affiliation
Horowitz, Julie E.
Unknown Affiliation
Baras, Aris
Unknown Affiliation
Abecasis, Gonçalo R.
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van Heel, David A.
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Hunt, Karen A.
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Mason, Dan
Unknown Affiliation
Finer, Sarah
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Trivedi, Bhavi
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Griffiths, Christopher J.
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Martin, Hilary C.
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Wright, John P.
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Trembath, Richard C.
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Zhao, Jinghua
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Butterworth, Adam S.
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Danesh, John N.
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Di Angelantonio, Emanuele
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Deelen, Patrick
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Claringbould, Annique
Unknown Affiliation
Vonk, Judith M.
Unknown Affiliation
Ori, Anil P.S.
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Beck, Andrew T.
Unknown Affiliation
Peloso, Gina Marie
Unknown Affiliation
Ho, Yuklam
Unknown Affiliation
Sun, Yan V.
Unknown Affiliation
Huffman, Jennifer E.
Unknown Affiliation
O'Donnell, Christopher J.
Unknown Affiliation
Cho, Kelly
Unknown Affiliation
Nivard, Michel G.
Unknown Affiliation
de Geus, Eco J.C.N.
Unknown Affiliation
Bartels, Meike
Unknown Affiliation
Hottenga, Jouke Jan
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Weiss, Scott T.
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Karlson, Elizabeth W.
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Smoller, Jordan Wassertheil
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Green, Robert C.
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Mercader, Josep Maria
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Murphy, Shawn N.
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Meigs, James B.
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Woolley, Ann E.
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Rader, Daniel J.
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Verma, Anurag
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Ritchie, Marylyn D.
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Verma, Shefali Setia
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Lucas, Anastasia Marie
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Bradford, Yuki
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Zeberg, Hugo
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Frithiof, Robert
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Hultström, Michael
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Lipcsey, Miklös
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Nakanishi, Tomoko
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Karczewski, Konrad J.
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Atkinson, Elizabeth Grace
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Kanai, Masahiro
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Tsuo, Kristin
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Baya, Nikolas
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Turley, Patrick A.
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Gupta, Rahul
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Callier, Shawneequa L.
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Walters, Raymond K.
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Palmer, Duncan S.
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Zhou, Wei
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Finucane, Hilary K.
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Martin, Alicia R.
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Bryant, Sam
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Wilson, Daniel J.
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Band, Gavin
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Earle, Sarah G.
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Crook, Derrick W.M.
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Wyllie, David H.
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Spencer, Chris C.A.
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Scott, Richard H.
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Fowler, Tom A.
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Moutsianas, Loukas
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Kousathanas, Athanasios
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Pasko, Dorota
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Walker, Susan
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Rendon, Augusto
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Stuckey, Alexander
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Odhams, Christopher A.
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Rhodes, Daniel
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Chan, Georgia C.
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Arumugam, Prabhu
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Rand, Kristin A.
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Sloofman, Laura G.
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Charney, Alexander W.
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Beckmann, Noam D.
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Schadt, Eric E.
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Jordan, Daniel M.
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Thompson, Ryan C.
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Gettler, Kyle A.
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Ascolillo, Steven
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Buxbaum, Joseph D.
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Cho, Judy H.
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Itan, Yuval
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Kenny, Eimear E.
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Belbin, Gillian Morven
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Sealfon, Stuart C.
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Sebra, Robert P.
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Collins, Brett L.
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Preuss, Michael H.
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Loos, Ruth J.F.
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Nadkarni, Girish N.
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Do, Ron
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Hoggart, Clive J.
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Huckins, Laura
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Statistics
Citations: 19
Authors: 358
Affiliations: 1
Identifiers
Doi:
10.1016/j.celrep.2021.110020
ISSN:
22111247
Research Areas
Covid
Genetics And Genomics
Study Approach
Quantitative