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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Elevated serum levels of IL-1ra in children with Plasmodium falciparum malaria are associated with increased severity of disease
Cytokine, Volume 41, No. 3, Year 2008
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Description
Animal models suggest that cytokines and chemokines play a role in cerebral malaria (CM) pathogenesis, but levels of a number of cytokines and chemokines thought to be important in the pathogenesis of other infectious diseases are not well characterized in children with CM. Serum levels of granulocyte-colony stimulating factor (G-CSF), interleukin-1 receptor antagonist (IL-1ra), interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) were measured in 77 children with CM, 70 children with uncomplicated malaria (UM) and 63 healthy community children (CC) in Uganda. Children with CM had elevated serum levels of IL-1ra and IL-8 as compared to children with UM (median levels in pg/ml, 11,891 vs. 6510, P = 0.05, and 63 vs. 41, P = 0.01, respectively). Children with CM who died (n = 4) had higher serum levels than survivors of IL-1ra (median levels in pg/ml, 65,757 vs. 10,355, P = 0.02), G-CSF (709 vs. 117, P = 0.02), and MCP-1 (1275 vs. 216, P = 0.03) but not IL-8 (76 vs. 62, P = NS). Elevated IL-1ra levels are associated with increased disease severity in children with malaria, and very elevated levels of IL-1ra, G-CSF and MCP-1 are seen in children who die of CM. © 2007 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
John, Chandy Chiramukhathu
United States, Minneapolis
University of Minnesota Medical School
Park, Gregory S.
United States, Minneapolis
University of Minnesota Medical School
Sam-Agudu, Nadia Adjoa
United States, Minneapolis
University of Minnesota Medical School
Opoka, Robert Opika
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Boivin, Michael Joseph
United States, East Lansing
Msu College of Osteopathic Medicine
Statistics
Citations: 55
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.cyto.2007.12.008
ISSN:
10434666
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Uganda