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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Down-regulation of granulocyte-macrophage colony-stimulating factor by 3C-like proteinase in transfected A549 human lung carcinoma cells
BMC Immunology, Volume 12, Article 16, Year 2011
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Description
Background: Severe Acute Respiratory Syndrome (SARS) is a severe respiratory illness caused by a novel virus, the SARS coronavirus (SARS-CoV). 3C-like protease (3CLpro) of SARS-CoV plays a role in processing viral polypeptide precursors and is responsible of viral maturation. However, the function of 3CLpro in host cells remains unknown. This study investigated how the 3CLpro affected the secretion of cytokines in the gene-transfected cells.Results: From immunofluorescence microscopy, the localization of c-myc tagged 3CLpro was detected both in the cytoplasm and nucleus of transfected A549 cells. Expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) was significantly decreased in 3CLpro-transfected cells by both RT-PCR and ELISA, but without changes in other cytokines, i.e., IL-1β, IL-6, IL-8, IL12p40, TNF-α, and TGF-β. Furthermore, the protein levels of NF-kB decreased in 3CLpro-transfected A549 cells when compared to EGFP transfected cells.Conclusions: Our results suggest that the 3CLpro may suppress expression of GM-CSF in transfected A549 cells through down-regulation of NF-kB production. © 2011 Liao et al; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3048559/bin/1471-2172-12-16-S1.PPT
Authors & Co-Authors
Liao, Hsien Hua
Taiwan, Taichung
Chung Shan Medical University
Taiwan, Taichung
Chung Shan Medical University Hospital
Wang, Yaochen
Taiwan, Taichung
Chung Shan Medical University
Taiwan, Taichung
Chung Shan Medical University Hospital
Chen, Miles Chih Ming
Taiwan, Taipei
Academia Sinica, Institute of Biological Chemistry
Tsai, Hsien Yu
Taiwan, Taipei
Academia Sinica, Institute of Biological Chemistry
Taiwan, Taipei
National Taiwan University
Lin, Johnson
Taiwan, Taipei
Academia Sinica, Institute of Biological Chemistry
South Africa, Durban
University of Kwazulu-natal
Chen, Shui Tein
Taiwan, Taipei
Academia Sinica, Institute of Biological Chemistry
Taiwan, Taipei
National Taiwan University
Taiwan, Taipei
Academia Sinica, Genomics Research Center
Tsay, Gregory Jiazer
Taiwan, Taichung
Chung Shan Medical University Hospital
Taiwan, Taichung
Chung Shan Medical University
Cheng, Sunlong
Taiwan, Taichung
Chung Shan Medical University Hospital
Statistics
Citations: 13
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1186/1471-2172-12-16
e-ISSN:
14712172
Research Areas
Cancer
Covid
Genetics And Genomics