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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Novel Pd(ii)-salen complexes showing high in vitro anti-proliferative effects against human hepatoma cancer by modulating specific regulatory genes
Dalton Transactions, Volume 41, No. 35, Year 2012
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Description
We have reported the synthesis of a novel salen ligand and its mononuclear Pd-salen complexes derived from 2-{[2-hydroxy-3-{[(E)-(2-hydroxyphenyl) methylidene]amino}propyl)imino]methyl}phenol. The newly synthesized and isolated Pd(ii) complexes have been identified and fully characterized by various physico-chemical studies viz., elemental analyses, IR, UV-Vis, 1H, 13C NMR spectroscopy, electron spray ionization mass spectrometry (ESI-MS) and TGA/DTA studies. The molecular structure of the salen ligand has been ascertained by single-crystal XRD and it is coordinated to Pd(ii) ion through two nitrogen and two oxygen atoms. The UV-Vis data clearly suggest a square-planar environment around both the Pd(ii) ions. The DNA binding studies of the synthesized compounds has been investigated by electron spectroscopy and fluorescence measurements. The results suggest that Pd(ii) complexes bind to DNA strongly as compared to the free ligand. The free salen ligand and its Pd(ii) complexes have also been tested against human hepatoma cancer cell line (Huh7) and results manifested exceptional anti-proliferative effects of the Pd(ii) complexes. The anti-proliferative activity of Pd(ii) complexes has been modulated by specific regulatory genes. © 2012 The Royal Society of Chemistry.
Authors & Co-Authors
Azam, Mohammad W.
Saudi Arabia, Riyadh
King Saud University
Hussain, Zahid
Saudi Arabia, Riyadh
King Saud University
Warad, I. Khaleel
Saudi Arabia, Riyadh
King Saud University
Al-Resayes, Saud Ibrahim
Saudi Arabia, Riyadh
King Saud University
Shahnawaz Khan, Mohd Shahhnawaz
Saudi Arabia, Riyadh
King Saud University
Shakir, Mohammad Lutfullah
India, Aligarh
Aligarh Muslim University
Trzęsowska-Kruszyńska, Agata
Poland, Lodz
Lodz University of Technology
Kruszyński, Rafał
Poland, Lodz
Lodz University of Technology
Statistics
Citations: 46
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1039/c2dt31143g
ISSN:
14779226
e-ISSN:
14779234
Research Areas
Cancer
Genetics And Genomics