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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Preventing IUCD‐related pelvic infection: the efficacy of prophylactic doxycycline at insertion
BJOG: An International Journal of Obstetrics & Gynaecology, Volume 97, No. 5, Year 1990
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Description
Summary. Most of the small increased risk in pelvic inflammatory disease (PID) associated with the intrauterine contraceptive device (IUCD) appears to be caused by bacterial contamination of the endometrial cavity at the time of insertion. This randomized clinical trial of 1813 women in Nairobi, Kenya, assessed the effectiveness of 200 mg of doxycycline given orally at the time of insertion in reducing the occurrence of PID. The rate of this infection in the doxycycline‐treated group was 31% lower than that in the placebo‐treated group (1.3 and 1.9%, respectively; RR 0.69; 95% CI 0.32 to 1–5). The rate of an unplanned IUCD‐related visit to the clinic was also 31% lower in the doxycycline‐treated group (RR 0.69; 95% CI 0.52 to 0.91). Although the significance level (P = 0.17) for the reduction is PID does not meet the conventional standard of 0.05, the results may be suggestive of an effect. Moreover, the reduction in IUCD‐related visits (P = 0.004) not only represents an important decrease in morbidity but also substantiates the reduction found for PID. Further studies are needed to corroborate these results. Consideration should be given to the prophylactic use of doxycycline at the time of IUCD insertion as an approach to preventing PID and other lUCD‐related morbidity. Copyright © 1990, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Sinei, Samuel K.A.
Kenya, Nairobi
University of Nairobi Medical School
Schulz, Kenneth F.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Lamptey, Peter R.
United States, Durham
Fhi 360
Grimes, David A.
United States, Los Angeles
Keck School of Medicine of Usc
Mati, Japheth K.G.
Kenya, Nairobi
University of Nairobi Medical School
Rosenthal, Steven M.
United States, Durham
Fhi 360
Rosenberg, Michael J.
United States, Durham
Fhi 360
Riara, G.
Kenya, Nairobi
University of Nairobi Medical School
Njage, P. N.
Kenya, Nairobi
University of Nairobi Medical School
Bhullar, Vini B.
Kenya, Nairobi
University of Nairobi Medical School
Ogembo, H. V.
Kenya, Nairobi
University of Nairobi Medical School
Statistics
Citations: 64
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1111/j.1471-0528.1990.tb01828.x
ISSN:
14700328
e-ISSN:
14710528
Research Areas
Health System And Policy
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Study Locations
Kenya
Participants Gender
Female