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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Ammonium hydroxide extracts from black tea inhibit growth, migration and invasion of colon cancer cells
Journal of Food Biochemistry, Volume 32, No. 2, Year 2008
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Description
In this study, the effects of ammonium hydroxide extracts from black tea on colon cancer cells were analyzed. Here we showed that black tea extracts decreased the growth of SW480 and HCT116 cells in a dose-dependent manner. The increase of subG1 population indicated that the black tea extracts induced cancer cell death. In addition, cell migration and invasion were significantly inhibited by the black tea extracts. We also found that tyrosine phosphorylation of focal adhesion kinase and paxillin was decreased in these cells, suggesting that integrin signaling pathways were affected by the extracts. In addition, decreased phosphorylation of extracellular signal-regulated kinase and increased phosphorylation of p38 and c-Jun N-terminal kinase were observed, indicating that the extracts can modulate mitogen-activated protein kinase (MAPK) signaling pathways. These results suggest that the crude ammonium hydroxide extracts from black tea can significantly inhibit malignant phenotypes of colon cancer cells and that integrin and MAPK signaling pathways could be involved. © 2008, Blackwell Publishing.
Authors & Co-Authors
Huang, Hsiu Chin
Taiwan, Miao-li
Animal Technology Institute Taiwan
Taiwan, Miao-li
Prit Biotech Co., Ltd.
Chen, Hsiao Yu
United States, Ohio
College of Medicine
Chen, Chia Yang
Guinea, Health
College of Public
Shen, Tang Long
Taiwan, Taipei
National Taiwan University
Huang, John
Taiwan, Taipei
National Taiwan University Hospital
Lin, Neng Yu
United States, Ohio
College of Medicine
Sum, Shao Yin
United States, Ohio
College of Medicine
Che, Mei Ieng
United States, Ohio
College of Medicine
Huang, Min Chuan
United States, Ohio
College of Medicine
Taiwan, Taipei
National Taiwan University College of Medicine
Statistics
Citations: 9
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1111/j.1745-4514.2008.00152.x
ISSN:
01458884
e-ISSN:
17454514
Research Areas
Cancer
Study Design
Cross Sectional Study