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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant
Cell Reports Medicine, Volume 3, No. 7, Article 100679, Year 2022
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Description
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits reduced susceptibility to vaccine-induced neutralizing antibodies, requiring a boost to generate protective immunity. We assess the magnitude and short-term durability of neutralizing antibodies after homologous and heterologous boosting with mRNA and Ad26.COV2.S vaccines. All prime-boost combinations substantially increase the neutralization titers to Omicron, although the boosted titers decline rapidly within 2 months from the peak response compared with boosted titers against the prototypic D614G variant. Boosted Omicron neutralization titers are substantially higher for homologous mRNA vaccine boosting, and for heterologous mRNA and Ad26.COV2.S vaccine boosting, compared with homologous Ad26.COV2.S boosting. Homologous mRNA vaccine boosting generates nearly equivalent neutralizing activity against Omicron sublineages BA.1, BA.2, and BA.3 but modestly reduced neutralizing activity against BA.2.12.1 and BA.4/BA.5 compared with BA.1. These results have implications for boosting requirements to protect against Omicron and future variants of SARS-CoV-2. This trial was conducted under ClincalTrials.gov: NCT04889209. © 2022 The Authors
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9212999/bin/mmc1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC9212999/bin/mmc2.pdf
Authors & Co-Authors
Lyke, Kirsten E.
United States, Baltimore
University of Maryland School of Medicine
Atmar, Robert L.
United States, Houston
Baylor College of Medicine
Islas, Clara Dominguez
United States, Seattle
Fred Hutchinson Cancer Center
Posavad, Christine M.
United States, Seattle
Fred Hutchinson Cancer Center
Szydlo, Daniel W.
United States, Seattle
Fred Hutchinson Cancer Center
Deming, Meagan E.
United States, Baltimore
University of Maryland School of Medicine
Eaton, Amanda
United States, Durham
Duke University Medical Center
Jackson, Lisa A.
United States, Oakland
Kaiser Permanente
Branche, Angela R.
United States, Rochester
University of Rochester
El-Sahly, Hana Mohammed
United States, Houston
Baylor College of Medicine
Martin, Judith Marie
United States, Pittsburgh
University of Pittsburgh School of Medicine
Johnston, Christine M.
United States, Seattle
Fred Hutchinson Cancer Center
United States, Seattle
University of Washington
Rupp, Richard E.
United States, Galveston
The University of Texas Medical Branch at Galveston
Mulligan, Mark J.
United States, New York
Nyu Langone Health
Frenck, Robert W.
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Babu, Tara M.
United States, Seattle
University of Washington
Edupuganti, Srilatha
United States, Atlanta
Emory University School of Medicine
United States, Atlanta
Emory University
Coler, Rhea N.
United States, Seattle
Children's Hospital and Regional Medical Center
United States, Seattle
University of Washington School of Medicine
Zemanek, Jillian A.
United States, Seattle
Fred Hutchinson Cancer Center
Brown, Elizabeth R.
United States, Seattle
Fred Hutchinson Cancer Center
Neuzil, Kathleen Maletic
United States, Baltimore
University of Maryland School of Medicine
Stephens, David
United States, Atlanta
Emory University School of Medicine
Suthar, Mehul S.
United States, Atlanta
Emory University
Beigel, John H.
United States, Bethesda
National Institutes of Health Nih
Montefiori, David Charles
United States, Durham
Duke University Medical Center
Husson, Jennifer S.
Unknown Affiliation
Falsey, Ann Regina
Unknown Affiliation
Graciaa, Daniel S.
Unknown Affiliation
Rouphael, Nadine G.
Unknown Affiliation
Anderson, Evan J.
Unknown Affiliation
Bhatnagar, Sonika
Unknown Affiliation
Wald, Anna
Unknown Affiliation
Carsons, Steven E.
Unknown Affiliation
Hural, John A.
Unknown Affiliation
Statistics
Citations: 77
Authors: 34
Affiliations: 19
Identifiers
Doi:
10.1016/j.xcrm.2022.100679
ISSN:
26663791
Research Areas
Covid