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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Identification of MW polyomavirus, a novel polyomavirus in human stool
Journal of Virology, Volume 86, No. 19, Year 2012
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Description
We have discovered a novel polyomavirus present in multiple human stool samples. The virus was initially identified by shotgun pyrosequencing of DNA purified from virus-like particles isolated from a stool sample collected from a healthy child from Malawi. We subsequently sequenced the virus' 4,927-bp genome, which has been provisionally namedMWpolyomavirus (MWPyV). The virus has genomic features characteristic of the family Polyomaviridae but is highly divergent from other members of this family. It is predicted to encode the large T antigen and small T antigen early proteins and the VP1, VP2, and VP3 structural proteins. A real-time PCR assay was designed and used to screen 514 stool samples from children with diarrhea in St. Louis, MO; 12 specimens were positive for MWPyV. Comparison of the whole-genome sequences of the index Malawi case and one St. Louis case demonstrated that the two strains of MWPyV varied by 5.3% at the nucleotide level. The number of polyomaviruses found in the human body continues to grow, raising the question of how many more species have yet to be identified and what roles they play in humans with and without manifest disease. © 2012 American Society for Microbiology.
Authors & Co-Authors
Siebrasse, Erica A.
United States, St. Louis
Washington University School of Medicine in St. Louis
Reyes, Alejandro
United States, St. Louis
Washington University School of Medicine in St. Louis
Lim, Efrem S.
United States, St. Louis
Washington University School of Medicine in St. Louis
Zhao, Guoyan
United States, St. Louis
Washington University School of Medicine in St. Louis
Mkakosya, Rajhab Sawasawa
Malawi, Zomba
University of Malawi
Manary, Mark J.
United States, St. Louis
Washington University School of Medicine in St. Louis
Gordon, Jeffrey I.
United States, St. Louis
Washington University School of Medicine in St. Louis
Wang, David
United States, St. Louis
Washington University School of Medicine in St. Louis
Statistics
Citations: 192
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1128/JVI.01210-12
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Locations
Malawi