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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Viral and atypical bacterial etiology of acute respiratory infections in children under 5 years old living in a rural tropical area of madagascar
PLoS ONE, Volume 7, No. 8, Article e43666, Year 2012
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Description
Background: In Madagascar, very little is known about the etiology and prevalence of acute respiratory infections (ARIs) in a rural tropical area. Recent data are needed to determine the viral and atypical bacterial etiologies in children with defined clinical manifestations of ARIs. Methods: During one year, we conducted a prospective study on ARIs in children between 2 to 59 months in the community hospital of Ampasimanjeva, located in the south-east of Madagascar. Respiratory samples were analyzed by multiplex real-time RT-PCR, including 18 viruses and 2 atypical bacteria. The various episodes of ARI were grouped into four clinical manifestations with well-documented diagnosis: "Community Acquired Pneumonia"(CAP, group I), "Other acute lower respiratory infections (Other ALRIs, group II)", "Upper respiratory tract infections with cough (URTIs with cough, group III)"and "Upper respiratory tract infections without cough (URTIs without cough, group IV)". Results: 295 children were included in the study between February 2010 and February 2011. Viruses and/or atypical bacteria respiratory pathogens were detected in 74.6% of samples, the rate of co-infection was 27.3%. Human rhinovirus (HRV; 20.5%), metapneumovirus (HMPV A/B, 13.8%), coronaviruses (HCoV, 12.5%), parainfluenza virus (HPIV, 11.8%) and respiratory syncytial virus A and B (RSV A/B, 11.8%) were the most detected. HRV was predominantly single detected (23.8%) in all the clinical groups while HMPV A/B (23.9%) was mainly related to CAP (group I), HPIV (17.3%) to the "Other ALRIs" (group II), RSV A/B (19.5%) predominated in the group "URTIs with cough" (group III) and Adenovirus (HAdV, 17.8%) was mainly detected in the "without cough" (group IV). Interpretation: This study describes for the first time the etiology of respiratory infections in febrile children under 5 years in a malaria rural area of Madagascar and highlights the role of respiratory viruses in a well clinically defined population of ARIs. © 2012 Hoffmann et al.
Authors & Co-Authors
Hoffmann, Jonathan
Madagascar, Antananarivo
Faculty of Medicine
Madagascar, Antananarivo
Fondation Mérieux
Rabezanahary, Henintsoa Manarivo
Madagascar, Antananarivo
Faculty of Medicine
Randriamarotia, Martin
Unknown Affiliation
Ratsimbasoa, Arsène C.
Madagascar, Antananarivo
Fondation Mérieux
Madagascar, Antananarivo
Ministère de la Santé Publique
Najjar, Josette
France, Lyon
Biosciences Gerland-lyon Sud
Vernet, Guy
France, Lyon
Biosciences Gerland-lyon Sud
Contamin, Bénédicte
Madagascar, Antananarivo
Faculty of Medicine
Madagascar, Antananarivo
Fondation Mérieux
Paranhos-Baccalá, Gláucia S.
France, Lyon
Biosciences Gerland-lyon Sud
Statistics
Citations: 60
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0043666
e-ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Madagascar