Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Susceptibility to Yersinia pestis experimental infection in wild rattus rattus, reservoir of plague in Madagascar
EcoHealth, Volume 7, No. 2, Year 2010
Notification
URL copied to clipboard!
Description
In Madagascar, the black rat, Rattus rattus, is the main reservoir of plague (Yersinia pestis infection), a disease still responsible for hundreds of cases each year in this country. This study used experimental plague challenge to assess susceptibility in wild-caught rats to better understand how R. rattus can act as a plague reservoir. An important difference in plague resistance between rat populations from the plague focus (central highlands) and those from the plague-free zone (low altitude area) was confirmed to be a widespread phenomenon. In rats from the plague focus, we observed that sex influenced plague susceptibility, with males slightly more resistant than females. Other individual factors investigated (weight and habitat of sampling) did not affect plague resistance. When infected at high bacterial dose (more than 10 5 bacteria injected), rats from the plague focus died mainly within 3-5 days and produced specific antibodies, whereas after low-dose infection (< 5,000 bacteria), delayed mortality was observed and surviving seronegative rats were not uncommon. These results concerning plague resistance level and the course of infection in the black rat would contribute to a better understanding of plague circulation in Madagascar. © 2010 International Association for Ecology and Health.
Authors & Co-Authors
Tollenaere, Charlotte
France, Montpellier
Inrae's Occitanie-montpellier Centre
Rahalison, Lila
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Ranjalahy, Michel A.
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Duplantier, Jean Marc
France, Montpellier
Inrae's Occitanie-montpellier Centre
Rahelinirina, Soanandrasana
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Telfer, Sandra E.
United Kingdom, Aberdeen
University of Aberdeen
Brouat, Carine
France, Montpellier
Inrae's Occitanie-montpellier Centre
Statistics
Citations: 43
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1007/s10393-010-0312-3
ISSN:
16129202
Study Locations
Madagascar
Participants Gender
Female