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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Synthesis and screening of some novel fused thiophene and thienopyrimidine derivatives for anti-avian influenza virus (H5N1) activity
European Journal of Medicinal Chemistry, Volume 45, No. 11, Year 2010
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Description
Several derivatives containing dihydronaphtho, naphtho[2,1-b]thiophene and thieno[2,3-d]pyrimidine ring systems were prepared starting from 2-amino-4,5-dihydronaphtho[2,1-b]thiophene-1-carbonitrile (1). Structure characterization of the thioxo derivative 7 was also performed and its reaction with some chloro and bromoalkyl reagents was studied. Moreover, the prepared products were tested for antiviral activity against H5N1 virus [A/chicken/Egypt/1/2006 (H5N1)] by determination of both EC50 and LD50 and confirmed by plaque reduction assay on MDCK cells. Compounds 5, 7 and 8 showed the highest effect compared with the other tested compounds. © 2010 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Rashad, Aymn E.
Egypt, Giza
National Research Centre
Shamroukh, Ahmed Hussien
Egypt, Giza
National Research Centre
El-Mageid, Randa Sayed Abd
Egypt, Giza
National Research Centre
Mostafa, Ahmed
Egypt, Giza
National Research Centre
El-Shesheny, Rabeh A.
Egypt, Giza
National Research Centre
Kandeil, A. Mohamed
Egypt, Giza
National Research Centre
Ali, Mohamed Ahmed A.
Egypt, Giza
National Research Centre
Banert, Klaus
Germany, Chemnitz
Technische Universität Chemnitz
Statistics
Citations: 95
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/j.ejmech.2010.08.044
ISSN:
02235234
e-ISSN:
17683254
Study Locations
Egypt