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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009–15
Clinical Microbiology and Infection, Volume 24, No. 12, Year 2018
Notification
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Description
Objectives: Antimicrobial resistance (AMR) is a priority for surveillance in bacterial infections. For leprosy, AMR has not been assessed because Mycobacterium leprae does not grow in vitro. We aim to obtain AMR data using molecular detection of resistance genes and to conduct a prospective open survey of resistance to antileprosy drugs in countries where leprosy is endemic through a WHO surveillance network. Methods: From 2009 to 2015, multi-bacillary leprosy cases at sentinel sites of 19 countries were studied for resistance to rifampicin, dapsone and ofloxacin by PCR sequencing of the drug-resistance-determining regions of the genes rpoB, folP1 and gyrA. Results: Among 1932 (1143 relapse and 789 new) cases studied, 154 (8.0%) M. leprae strains were found with mutations conferring resistance showing 182 resistance traits (74 for rifampicin, 87 for dapsone and 21 for ofloxacin). Twenty cases showed rifampicin and dapsone resistance, four showed ofloxacin and dapsone resistance, but no cases were resistant to rifampicin and ofloxacin. Rifampicin resistance was observed among relapse (58/1143, 5.1%) and new (16/789, 2.0%) cases in 12 countries. India, Brazil and Colombia reported more than five rifampicin-resistant cases. Conclusions: This is the first study reporting global data on AMR in leprosy. Rifampicin resistance emerged, stressing the need for expansion of surveillance. This is also a call for vigilance on the global use of antimicrobial agents, because ofloxacin resistance probably developed in relation to the general intake of antibiotics for other infections as it is not part of the multidrug combination used to treat leprosy. © 2018 The Authors
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6286419/bin/mmc1.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC6286419/bin/mmc2.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC6286419/bin/mmc3.docx
Authors & Co-Authors
Cambau, Emmanuelle E.
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Saunderson, Paul R.
United States, Greenville
American Leprosy Missions
Matsuoka, Masanori
Japan, Tokyo
National Institute of Infectious Diseases
Cole, Stewart Thomas
Switzerland, Lausanne
École Polytechnique Fédérale de Lausanne
France, Paris
Fondation Raoul Follereau
Kai, Masanori
Japan, Tokyo
National Institute of Infectious Diseases
Suffys, Philip Noel
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Rosa, Patrícia Sammarco
Brazil, Bauru
Instituto Lauro de Souza Lima
Williams, Diana Lynn
Unknown Affiliation
Miyamoto, Yuji
Japan, Tokyo
National Institute of Infectious Diseases
Hagge, Deanna Alisa
Nepal, Kathmandu
Anandaban Leprosy Hospital
Johnson, Roch Christian
France, Paris
Fondation Raoul Follereau
Cauchoix, Bertrand
France, Paris
Fondation Raoul Follereau
Pemmaraju, Venkata Rao R.
India, New Delhi
Who Regional Office for South-east Asia
Al-Samie, Abdul Rahim
Unknown Affiliation
Tiendrébéogo, Alexandre
Unknown Affiliation
Kingalu, Amri Miraju
Unknown Affiliation
Randrianantoandro, Andriamira
Unknown Affiliation
Kumar, Anil M.V.
Unknown Affiliation
Chauffour, Aurélie
Unknown Affiliation
Pandey, Basu Dev
Unknown Affiliation
Schmotzer, Christine L.
Unknown Affiliation
Kafando, Christophe
Unknown Affiliation
Bhandari, Chuda Mani
Unknown Affiliation
Semá, Cynthia Baltazar
Unknown Affiliation
Vidanagama, Dhammika Sirisena
Unknown Affiliation
Beyene, Demissew
Unknown Affiliation
Claco, Eric
Unknown Affiliation
Villalon, Ernesto E.S.
Unknown Affiliation
Sakho, Fatoumata
Unknown Affiliation
Thakur, Garib Das
Unknown Affiliation
Sock, Gouressi
Unknown Affiliation
Kawuma, Herman Joseph S.
Unknown Affiliation
Goulart, Isabela Maria Bernardes
Unknown Affiliation
Matheu, Jorge R.
Unknown Affiliation
Neupane, Kapil Dev
Unknown Affiliation
Bide, Landry
Unknown Affiliation
Shah, Mahesh
Unknown Affiliation
Kodio, Mamoudou
Unknown Affiliation
Grossi, Maria Aparecida De Faria
Unknown Affiliation
Balagon, Maria Victoria F.
Unknown Affiliation
Ishii, Norishisa
Unknown Affiliation
Amiel, Olga Nelson
Unknown Affiliation
Krishnamurthy, Padebettu
Unknown Affiliation
Brennan, Patrick Joseph
Unknown Affiliation
Busso, Philippe
Unknown Affiliation
Rakoto-Andrianarivelo, Mala
Unknown Affiliation
Cho, Sangnae Ray
Unknown Affiliation
Kamara, Vedastus Deusdedit
Unknown Affiliation
Al-Qubati, Yasin A.
Unknown Affiliation
Suzuki, Yasuhiko
Unknown Affiliation
Statistics
Citations: 111
Authors: 50
Affiliations: 15
Identifiers
Doi:
10.1016/j.cmi.2018.02.022
ISSN:
1198743X
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative