Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Cholera epidemic associated with consumption of unsafe drinking water and street-vended water-Eastern Freetown, Sierra Leone, 2012
American Journal of Tropical Medicine and Hygiene, Volume 90, No. 3, Year 2014
Notification
URL copied to clipboard!
Description
During 2012, Sierra Leone experienced a cholera epidemic with 22,815 reported cases and 296 deaths. We conducted a matched case-control study to assess risk factors, enrolling 49 cases and 98 controls. Stool specimens were analyzed by culture, polymerase chain reaction (PCR), and pulsed-field gel electrophoresis (PFGE). Conditional logistic regression found that consuming unsafe water (matched odds ratio [mOR]: 3.4; 95% confidence interval [CI]: 1.1, 11.0), street-vended water (mOR: 9.4; 95% CI: 2.0, 43.7), and crab (mOR: 3.3; 95% CI: 1.03, 10.6) were significant risk factors for cholera infection. Of 30 stool specimens, 13 (43%) showed PCR evidence of toxigenic Vibrio cholerae O1. Six specimens yielded isolates of V. cholerae O1, El Tor; PFGE identified a pattern previously observed in seven countries. We recommended ensuring the quality of improved water sources, promoting household chlorination, and educating street vendors on water handling practices. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Sreenivasan, Nandini
United States, Atlanta
Centers for Disease Control and Prevention
Lam, Eugene K.
United States, Atlanta
Centers for Disease Control and Prevention
Ayers, Tracy L.
United States, Atlanta
Centers for Disease Control and Prevention
Kargbo, David Kabba
United States, Atlanta
Centers for Disease Control and Prevention
Dafae, Foday Mohamed
United States, Atlanta
Centers for Disease Control and Prevention
Jambai, Amara A.
United States, Atlanta
Centers for Disease Control and Prevention
Alemu, Wondimagegnehu
Switzerland, Geneva
Organisation Mondiale de la Santé
Kamara, Abdul H.
United States, Atlanta
Centers for Disease Control and Prevention
Islam, Mohammad Sirajul
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Stroika, Steven G.
United States, Atlanta
Centers for Disease Control and Prevention
Bopp, Cheryl A.
United States, Atlanta
Centers for Disease Control and Prevention
Quick, Robert E.
United States, Atlanta
Centers for Disease Control and Prevention
Mintz, Eric Daniel
United States, Atlanta
Centers for Disease Control and Prevention
Brunkard, Joan Marie
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 50
Authors: 14
Affiliations: 3
Identifiers
Doi:
10.4269/ajtmh.13-0567
ISSN:
00029637
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Study Design
Case-Control Study
Study Locations
Sierra Leone