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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Chimpanzee malaria parasites related to Plasmodium ovale in Africa
PLoS ONE, Volume 4, No. 5, Article e5520, Year 2009
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Description
Since the 1970's, the diversity of Plasmodium parasites in African great apes has been neglected. Surprisingly, P. reichenowi, a chimpanzee parasite, is the only such parasite to have been molecularly characterized. This parasite is closely phylogenetically related to P. falciparum, the principal cause of the greatest malaria burden in humans. Studies of malaria parasites from anthropoid primates may provide relevant phylogenetic information, improving our understanding of the origin and evolutionary history of human malaria species. In this study, we screened 130 DNA samples from chimpanzees (Pan troglodytes) and gorillas (Gorilla gorilla) from Cameroon for Plasmodium infection, using cytochrome b molecular tools. Two chimpanzees from the subspecies Pan t. troglodytes presented single infections with Plasmodium strains molecularly related to the human malaria parasite P. ovale. These chimpanzee parasites and 13 human strains of P. ovale originated from a various sites in Africa and Asia were characterized using cytochrome b and cytochrome c oxidase 1 mitochondrial partial genes and nuclear ldh partial gene. Consistent with previous findings, two genetically distinct types of P. ovale, classical and variant, were observed in the human population from a variety of geographical locations. One chimpanzee Plasmodium strain was genetically identical, on all three markers tested, to variant P. ovale type. The other chimpanzee Plasmodium strain was different from P. ovale strains isolated from humans. This study provides the first evidence of possibility of natural cross-species exchange of P. ovale between humans and chimpanzees of the subspecies Pan t. troglodytes. © 2009 Duval et al.
Authors & Co-Authors
Duval, Linda
France, Paris
Museum National D'histoire Naturelle
France, Paris
Institut Pasteur, Paris
Nerrienet, Eric
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Rousset, Dominique
Cameroon, Yaounde
Centre Pasteur du Cameroun
Sadeuh-Mba, Serge Alain
Cameroon, Yaounde
Centre Pasteur du Cameroun
Houzé, Sandrine
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Fourment, Mathieu
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Australia, Sydney
Macquarie University
Le Bras, Jacques L.
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Robert, Vincent
France, Paris
Museum National D'histoire Naturelle
France, Montpellier
Ird Centre de Montpellier
Ariey, Frédéric
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Statistics
Citations: 75
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pone.0005520
e-ISSN:
19326203
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Cameroon