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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus
Experimental Dermatology, Volume 24, No. 7, Year 2015
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Description
Cutaneous lupus erythematosus (CLE) is a chronic autoimmune disease of the skin with typical clinical manifestations. Here, we genotyped 906 600 single nucleotide polymorphisms (SNPs) in 183 CLE cases and 1288 controls of Central European ancestry. Replication was performed for 13 SNPs in 219 case subjects and 262 controls from Finland. Association was particularly pronounced at 4 loci, all with genomewide significance (P < 5 × 10-8): rs2187668 (PGWAS = 1.4 × 10-12), rs9267531 (PGWAS = 4.7 × 10-10), rs4410767 (PGWAS = 1.0 × 10-9) and rs3094084 (PGWAS = 1.1 × 10-9). All mentioned SNPs are located within the major histocompatibility complex (MHC) region of chromosome 6 and near genes of known immune functions or associations with other autoimmune diseases such as HLA-DQ alpha chain 1 (HLA-DQA1), MICA, MICB, MSH5, TRIM39 and RPP21. For example, TRIM39/RPP21 read through transcript is a known mediator of the interferon response, a central pathway involved in the pathogenesis of CLE and systemic lupus erythematosus (SLE). Taken together, this genomewide analysis of disease association of CLE identified candidate genes and genomic regions that may contribute to pathogenic mechanisms in CLE via dysregulated antigen presentation (HLA-DQA1), apoptosis regulation, RNA processing and interferon response (MICA, MICB, MSH5, TRIM39 and RPP21). © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Authors & Co-Authors
Kunz, Manfred
Germany, Leipzig
Universität Leipzig
König, I. R.
Germany, Lubeck
Universität zu Lübeck
Schillert, Arne
Germany, Lubeck
Universität zu Lübeck
Kruppa, Jochen
Germany, Lubeck
Universität zu Lübeck
Ziegler, Andreas E.
Germany, Lubeck
Universität zu Lübeck
Grallert, Harald
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Müller-Nurasyid, Martina
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Ludwig-maximilians-universität München
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Lieb, Wolfgang S.
Germany, Kiel
Christian-albrechts-universität zu Kiel
Franke, Andre
Germany, Kiel
Christian-albrechts-universität zu Kiel
Ranki, Annamari M.
Finland, Helsinki
Helsinki University Hospital
Kere, Juha F.
Sweden, Stockholm
Karolinska Institutet
Finland, Helsinki
Folkhälsan Institute of Genetics
Simon, Jan Christoph
Germany, Leipzig
Universität Leipzig
Schmidt, Enno G.
Germany, Lubeck
Universitätsklinikum Schleswig-holstein Campus Lübeck
Zeller, Tanja
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Blankenberg, Stefan S.
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Gläser, Regine
Germany, Kiel
Universitätsklinikum Schleswig-holstein Campus Kiel
Kuhn, Annegret
Germany, Heidelberg
German Cancer Research Center
Ibrahim, Saleh Mohamed
Germany, Lubeck
Universitätsklinikum Schleswig-holstein Campus Lübeck
Statistics
Citations: 49
Authors: 18
Affiliations: 17
Identifiers
Doi:
10.1111/exd.12708
ISSN:
09066705
Research Areas
Cancer