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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The detection limits for estimates of infection intensity in schistosomiasis mansoni established by a study in non-human primates
International Journal for Parasitology, Volume 36, No. 12, Year 2006
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Description
In human schistosomiasis mansoni, it is impossible to directly determine worm burden and hence infection intensity, so surrogates must be used. Studies on non-human primates revealed a linear relationship between worm burden and three surrogates, faecal egg output, circulating anodic and circulating cathodic antigens. By regression, the thresholds of detection were determined as 40, 24 and 47 worms, respectively. These observations provide a quantitative basis for the contention that low intensity infections in humans are being missed. The significance for estimates of disease prevalence, evaluation of the effects of chemotherapy and the implementation of vaccine trials is emphasised. © 2006 Australian Society for Parasitology Inc.
Authors & Co-Authors
Alan Wilson, R.
United Kingdom, York
University of York
van Dam, Govert Jan
Netherlands, Leiden
Leids Universitair Medisch Centrum
Kariuki, Thomas M.
Kenya, Nairobi
National Museums of Kenya
Farah, Idle O.
Kenya, Nairobi
National Museums of Kenya
Deelder, André Martien
Netherlands, Leiden
Leids Universitair Medisch Centrum
Coulson, Patricia S.
United Kingdom, York
University of York
Statistics
Citations: 65
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.ijpara.2006.07.002
ISSN:
00207519
Research Areas
Cancer
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative