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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Molecular epidemiology and evolution of influenza viruses circulating within European swine between 2009 and 2013
Journal of Virology, Volume 89, No. 19, Year 2015
Notification
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Description
The emergence in humans of the A(H1N1)pdm09 influenza virus, a complex reassortant virus of swine origin, highlighted the importance of worldwide influenza virus surveillance in swine. To date, large-scale surveillance studies have been reported for southern China and North America, but such data have not yet been described for Europe. We report the first large-scale genomic characterization of 290 swine influenza viruses collected from 14 European countries between 2009 and 2013. A total of 23 distinct genotypes were identified, with the 7 most common comprising 82% of the incidence. Contrasting epidemiological dynamics were observed for two of these genotypes, H1huN2 and H3N2, with the former showing multiple long-lived geographically isolated lineages, while the latter had short-lived geographically diffuse lineages. At least 32 human-swine transmission events have resulted in A(H1N1)pdm09 becoming established at a mean frequency of 8% across European countries. Notably, swine in the United Kingdom have largely had a replacement of the endemic Eurasian avian virus-like ("avian-like") genotypes with A(H1N1)pdm09-derived genotypes. The high number of reassortant genotypes observed in European swine, combined with the identification of a genotype similar to the A(H3N2)v genotype in North America, underlines the importance of continued swine surveillance in Europe for the purposes of maintaining public health. This report further reveals that the emergences and drivers of virus evolution in swine differ at the global level. © 2015, American Society for Microbiology.
Authors & Co-Authors
Watson, Simon James
United Kingdom, Hinxton
Wellcome Sanger Institute
Langat, Pinky
United Kingdom, Hinxton
Wellcome Sanger Institute
Reid, Scott M.
United Kingdom, Addlestone
Animal and Plant Health Agency
Lam, Tommy Tsan Yuk
United Kingdom, Oxford
University of Oxford
Hong Kong, Hong Kong
The University of Hong Kong
Cotten, Matt
United Kingdom, Hinxton
Wellcome Sanger Institute
Chiapponi, Chiara
Italy, Brescia
Istituto Zooprofilattico Sperimentale Della Lombardia e Dell'emilia Romagna Bruno Ubertini
Larsen, Lars Erik
Denmark, Lyngby
Technical University of Denmark
Dürrwald, Ralf
Germany, Dessau-rosslau
Idt Biologika Gmbh
Dán, Ádám
Hungary, Budapest
National Food Chain Safety Office
Loeffen, Willie L.A.
Netherlands, Wageningen
Wageningen University & Research
Bublot, Michel
Germany, Ingelheim am Rhein
Boehringer Ingelheim International Gmbh
Maldonado, Jaime
Spain, Amer
Laboratorios Hipra, S.a.
Brown, Ian H.
United Kingdom, Addlestone
Animal and Plant Health Agency
Pybus, Oliver George
United Kingdom, Oxford
University of Oxford
Kellam, Paul
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, London
University College London
Statistics
Citations: 133
Authors: 15
Affiliations: 16
Identifiers
Doi:
10.1128/JVI.00840-15
ISSN:
0022538X
Research Areas
Genetics And Genomics
Study Design
Cohort Study