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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Adaptations to climate-mediated selective pressures in humans
PLoS Genetics, Volume 7, No. 4, Article e1001375, Year 2011
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Description
Humans inhabit a remarkably diverse range of environments, and adaptation through natural selection has likely played a central role in the capacity to survive and thrive in extreme climates. Unlike numerous studies that used only population genetic data to search for evidence of selection, here we scan the human genome for selection signals by identifying the SNPs with the strongest correlations between allele frequencies and climate across 61 worldwide populations. We find a striking enrichment of genic and nonsynonymous SNPs relative to non-genic SNPs among those that are strongly correlated with these climate variables. Among the most extreme signals, several overlap with those from GWAS, including SNPs associated with pigmentation and autoimmune diseases. Further, we find an enrichment of strong signals in gene sets related to UV radiation, infection and immunity, and cancer. Our results imply that adaptations to climate shaped the spatial distribution of variation in humans. © 2011 Hancock et al.
Available Materials
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https://efashare.b-cdn.net/share/pmc/articles/PMC3080864/bin/pgen.1001375.s007.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC3080864/bin/pgen.1001375.s008.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC3080864/bin/pgen.1001375.s009.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC3080864/bin/pgen.1001375.s010.xls
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https://efashare.b-cdn.net/share/pmc/articles/PMC3080864/bin/pgen.1001375.s012.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3080864/bin/pgen.1001375.s013.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3080864/bin/pgen.1001375.s014.doc
Authors & Co-Authors
Hancock, Angela M.
United States, Chicago
The University of Chicago
Witonsky, David B.
United States, Chicago
The University of Chicago
Alkorta-Aranburu, Gorka
United States, Chicago
The University of Chicago
Beall, Cynthia M.
United States, Cleveland
Case Western Reserve University
Gebremedhin, Amha
Ethiopia, Addis Ababa
Addis Ababa University
Sukernik, Rem I.
Russian Federation, Novosibirsk
Institute of Molecular and Cellular Biology of the Siberian Branch of the Ras
Utermann, Gerd
Austria, Innsbruck
Medizinische Universitat Innsbruck
Pritchard, Jonathan K.
United States, Chicago
The University of Chicago
United States, Chevy Chase
Howard Hughes Medical Institute
Coop, Graham
United States, Chicago
The University of Chicago
United States, Davis
University of California, Davis
Di Rienzo, Anna Maria
United States, Chicago
The University of Chicago
Statistics
Citations: 286
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pgen.1001375
e-ISSN:
15537404
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study