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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Asymptomatic Intestinal Colonization by Pathogenic Entamoeba histolytica in Amebic Liver Abscess: Prevalence, Response to Therapy, and Pathogenic Potential
Clinical Infectious Diseases, Volume 14, No. 4, Year 1992
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Description
Since the application of isoenzyme electrophoresis to the study of Entamoeba histolytica, the prevalence and natural history of asymptomatic intestinal colonization in patients with amebic liver abscess (ALA) has not been addressed. We prospectively evaluated this enteric phase in 50 patients with ALA, using two dosage regimens of metronidazole. The overall prevalence of asymptomatic colonization was 72% (36/50). All these isolates, without exception, proved to express pathogenic zymodemes. Despite a 100% clinical response of the hepatic lesions, failure to eradicate the organism from the bowel occurred in 20 of these 36 subjects. During longitudinal posttreatment surveillance, three carriers returned with second bouts of invasive disease: one with dysentery and two with liver abscesses. Thus, in patients with ALA, there is a high prevalence of intestinal colonization with exclusively pathogenic strains, and treatment with metronidazole frequently results in a continued carrier state. These carriers have a propensity for developing recurrent invasive disease and constitute a public health hazard. © 1992, by The University of Chicago.
Authors & Co-Authors
Irusen, Elvis Malcolm
South Africa, Congella
University of Natal, Faculty of Medicine
South Africa, Tygerberg
South African Medical Research Council
Jackson, Terry F.H.G.
South Africa, Congella
University of Natal, Faculty of Medicine
South Africa, Tygerberg
South African Medical Research Council
Simjee, Ahmed E.
South Africa, Congella
University of Natal, Faculty of Medicine
South Africa, Tygerberg
South African Medical Research Council
Statistics
Citations: 99
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1093/clinids/14.4.889
ISSN:
10584838
e-ISSN:
15376591
Research Areas
Environmental
Study Design
Cross Sectional Study
Cohort Study