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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with Schistosomes
Journal of Experimental Medicine, Volume 206, No. 11, Year 2009
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Description
Abnormal fibrosis occurs during chronic hepatic inflammations and is the principal cause of death in hepatitis C virus and schistosome infections. Hepatic fibrosis (HF) may develop either slowly or rapidly in schistosome-infected subjects. This depends, in part, on a major genetic control exerted by genes of chromosome 6q23. A gene (connective tissue growth factor [CTGF]) is located in that region that encodes a strongly fibrogenic molecule. We show that the single nucleotide polymorphism (SNP) rs9402373 that lies close to CTGF is associated with severe HF (P = 2 × 10-6; odds ratio [OR] = 2.01; confidence interval of OR [CI] = 1.51-2.7) in two Chinese samples, in Sudanese, and in Brazilians infected with either Schistosoma japonicum or S. mansoni. Furthermore, SNP rs12526196, also located close to CTGF, is independently associated with severe fibrosis (P = 6 × 10-4; OR = 1.94; CI = 1.32-2.82) in the Chinese and Sudanese subjects. Both variants affect nuclear factor binding and may alter gene transcription or transcript stability. The identified variants may be valuable markers for the prediction of disease progression, and identify a critical step in the development of HF that could be a target for chemotherapy. © 2009 Dessein et al.
Authors & Co-Authors
Dessein, Alain Jacques J.
France, Paris
Inserm
France, Marseille
Aix Marseille Université
France, Marseille
Hopital la Timone
Chevillard, Christophe
France, Paris
Inserm
France, Marseille
Aix Marseille Université
Arnaud, Violaine
France, Paris
Inserm
France, Marseille
Aix Marseille Université
Hou, Xunya
China, Yueyang
Hunan Institute of Parasitic Disease
Hamdoun, Anas Ahmed
Sudan, Wad Medani
Institute of Nuclear Medicine
Dessein, Hélia
France, Paris
Inserm
France, Marseille
Aix Marseille Université
He, Hongbin
China, Yueyang
Hunan Institute of Parasitic Disease
Abdelmaboud, Suzan A.
Sudan, Wad Medani
Institute of Nuclear Medicine
Luo, Xinsong
China, Yueyang
Hunan Institute of Parasitic Disease
Li, Jun
China, Yueyang
Hunan Institute of Parasitic Disease
Varoquaux, Arthur Damien
France, Paris
Inserm
France, Marseille
Aix Marseille Université
Mergani, Adil
Sudan, Wad Medani
Institute of Nuclear Medicine
Abdelwahed, Mohammed O.
Sudan, Wad Medani
Institute of Nuclear Medicine
Zhou, Jie
China, Yueyang
Hunan Institute of Parasitic Disease
Monis, Ahmed
Sudan, Wad Medani
Institute of Nuclear Medicine
Pitta, Maira G.R.
France, Paris
Inserm
France, Marseille
Aix Marseille Université
Gasmelseed, Nagla
Sudan, Wad Medani
Institute of Nuclear Medicine
Cabantous, Sandrine
France, Paris
Inserm
France, Marseille
Aix Marseille Université
Zhao, Yaqing
China, Yueyang
Hunan Institute of Parasitic Disease
Prata, Aluizio
Brazil, Uberaba
Universidade Federal do Triangulo Mineiro
Brandt, Carlos
Brazil, Recife
Universidade Federal de Pernambuco
Elwali, Nasr Eldin
Sudan, Wad Medani
Institute of Nuclear Medicine
Argiro, Laurent
France, Paris
Inserm
France, Marseille
Aix Marseille Université
Li, Yuesheng
China, Yueyang
Hunan Institute of Parasitic Disease
Australia, Brisbane
Royal Brisbane and Women's Hospital
Statistics
Citations: 58
Authors: 24
Affiliations: 8
Identifiers
Doi:
10.1084/jem.20090383
ISSN:
00221007
e-ISSN:
15409538
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Case-Control Study